QuickView for Eag1;jsessionid=B5E6B3841464EE31F77A99D286D399A5;jsessionid=A8CB71A0F115C439B9FCB9A349198956 (gene)

Gene Symbol:

KCNH1 Homo sapiens

Full name:

potassium voltage-gated channel subfamily H member 1

Synonyms:

EAG, EAG1, Kv10.1, TMBTS, ZLS1, h-eag, hEAG1, potassium voltage-gated channel subfamily H member 1, EAG channel 1, ether-a-go-go potassium channel 1, ether-a-go-go, Drosophila, homolog of, potassium channel, voltage gated eag related subfamily H, member 1, potassium voltage-gated channel, subfamily H (eag-related), member 1, voltage-gated potassium channel subunit Kv10.1

Genomic Location:

Chr 1: 208923178-209374080

Description:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume....

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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

1q32.2

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