QuickView for Edn1;jsessionid=A773C8BDD739D98594FA7D52882EE36A;jsessionid=359A2FFC54AF07788EF2DC4A3E0B9D47 (gene)

Gene Symbol:

Edn1 Mus musculus

Full name:

endothelin 1

Synonyms:

ET-1, PPET1, preproET, endothelin-1, preproendothelin-1

Genomic Location:

Chr 13: 42396845-42403359

Description:

This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of cent...

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This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a peptide before secretion by the vascular endothelial cells. The mature peptide has various biological activities such as vasoconstriction, cell proliferation, stimulation of hormone release and modulation of central nervous activity. Mice lacking the encoded protein exhibit neonatal lethality accompanied with numerous craniofacial and cardiovascular defects due to disruption in cranial and cardiac neural crest cell patterning during early embryogenesis.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA3_01 ,  EVI1_04 ,  OCT1_05 ,  AP1_Q4 ,  GATA_C ,  HAND1E47_01 ,  GFI1_01 ,  TATA_01 ,  NFAT_Q6 ,  AMEF2_Q6 ,  AREB6_02 ,  AREB6_04 ,  MEIS1AHOXA9_01 ,  FOXJ2_02 ,  STAT4_01 ,  STAT6_02 ,  CTTTAAR_UNKNOWN ,  HNF6_Q6 ,  HSF_Q6 ,  TCF1P_Q6 ,  SMAD3_Q6 ,  GATA_Q6 ,  SRF_Q4 ,  DR4_Q2 ,  ACATTCC_MIR1_MIR206 ,  AAGTCCA_MIR422B_MIR422A ,  CATTTCA_MIR203 ,  GGCACAT_MIR455 ,  AACATTC_MIR4093P ,  TTANTCA_UNKNOWN ,  CAGGTG_E12_Q6 ,  RTAAACA_FREAC2_01 ,  GATAAGR_GATA_C ,  TTCNRGNNNNTTC_HSF_Q6 ,  YTATTTTNR_MEF2_02 ,  TGCCAAR_NF1_Q6 ,  CATTGTYY_SOX9_B1 ,  TATAAA_TATA_01 ,  WGGAATGY_TEF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-455

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