QuickView for F2;jsessionid=4828180D5264C3C2F9249F29D3311CA4;jsessionid=31E904B8A982C2F9F2080CB26F539271;jsessionid=8E42096E6D7616D1316B1F6408766E29 (gene)

Gene Symbol:

F2 Homo sapiens

Full name:

coagulation factor II, thrombin

Synonyms:

PT, RPRGL2, THPH1, prothrombin, prepro-coagulation factor II, prothrombin B-chain, serine protease

Genomic Location:

Chr 11: 46697331-46717631

Description:

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against ...

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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MAZ_Q6 ,  HNF1_C ,  TGACCTY_ERR1_Q2 ,  HNF4_01 ,  CTTTGT_LEF1_Q2 ,  GCTNWTTGK_UNKNOWN ,  HNF1_Q6

Cytogenetic Map:

11p11.2

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