QuickView for FMO3;jsessionid=56482C3C608EC8D1DC9FBB4CF267A575;jsessionid=E409C28205AC0F7F2797E725D91AE746;jsessionid=F5D4D8942CC605DE5CE054F82541D0E5;jsessionid=1EB06429A1E69B3E3217913B07FA4D42 (gene)

Gene Symbol:

FMO3 Homo sapiens

Full name:

flavin containing monooxygenase 3

Synonyms:

FMOII, TMAU, dJ127D3.1, dimethylaniline monooxygenase [N-oxide-forming] 3, FMO form 2, dimethylaniline oxidase 3, hepatic flavin-containing monooxygenase-3, trimethylamine monooxygenase

Genomic Location:

Chr 1: 169326660-169353583

Description:

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and mult...

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Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HP1SITEFACTOR_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CTTTAAR_UNKNOWN

Cytogenetic Map:

1q24.3

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