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QuickView for GRG5;jsessionid=40E5A1F6E092C3F74389EDAE858120BD;jsessionid=B6646FEE9F97E92D5AA7E51C56453905 (gene)


Gene Symbol:
Aes Mus musculus Mus musculus
Full name:
amino-terminal enhancer of split
Synonyms:
AL024115, Esp1, Grg, Grg-5, Grg5, Tle5, amino-terminal enhancer of split, groucho-related protein 5, related to Drosophila groucho
Genomic Location:
Chr 10: 81022305-81029109
Description:
This gene encodes a protein that belongs to the Aes (amino-terminal enhancer of split) subgroup of the Groucho/transducin-like Enhancer of split (TLE) family of proteins that function as transcriptional corepressors. The encoded protein plays a role in neurological development and cell-fate determination. Alternatively spliced transcript variants h...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_010347
NR_074087
NM_001276288
Protein Names
Q06195
P63002
Q3TYD9
B7ZNK7



GO Molecular Function

repressing transcription factor binding | transcription corepressor activity | identical protein binding | protein binding | transcription factor binding | transcription coregulator activity

GO Biological Process

RNA metabolic process | response to extracellular stimulus | response to cytokine | response to interleukin-1 | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cellular response to extracellular stimulus | cellular process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | regulation of response to cytokine stimulus | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | regulation of binding | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | regulation of anoikis | cellular biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | regulation of gene expression | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | negative regulation of binding | biosynthetic process | aromatic compound biosynthetic process | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of RNA metabolic process | regulation of growth | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of programmed cell death | regulation of Wnt signaling pathway | transcription, DNA-templated | regulation of cell communication | positive regulation of anoikis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | cellular macromolecule biosynthetic process | developmental process | negative regulation of canonical Wnt signaling pathway | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | negative regulation of Wnt signaling pathway | skeletal system development | cellular metabolic process | regulation of cell death | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | transcription factor complex | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular