QuickView for GRK2;jsessionid=A58C1DA5E6B65245459735DE03B91B81;jsessionid=13A86D2890AACAF8CB42D36B1C87A78E (gene)
- Gene Symbol:
- Grk2
Rattus norvegicus - Full name:
- G protein-coupled receptor kinase 2
- Synonyms:
- Adrbk1, BARK1, GRK-2, beta-adrenergic receptor kinase 1, adrenergic receptor kinase, beta 1, adrenergic, beta, receptor kinase 1, beta-ARK-1, beta-adrenergic receptor kinase 1 beta ARK1
- Genomic Location:
- Chr 1: 206872995-206881108
- Description:
-
catalzyes phosphorylation of the beta-adrenergic receptor; may mediate desensitizaton of synaptic receptors; may regulate bone formation
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AP4_01 , AACTTT_UNKNOWN , AP4_Q5 , AP4_Q6 , MYB_Q6 , NFAT_Q6 , CEBPDELTA_Q6 , HOXA4_Q2 , PEA3_Q6 , LEF1_Q2
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
opioid receptor binding | enzyme binding | ribonucleotide binding | nucleotide binding | Edg-2 lysophosphatidic acid receptor binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | delta-type opioid receptor binding | G-protein coupled receptor kinase activity | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | scaffold protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | beta-adrenergic receptor kinase activity | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | kappa-type opioid receptor binding | G-protein coupled receptor binding | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | maintenance of protein location in nucleus | negative regulation of G-protein coupled receptor protein signaling pathway | negative regulation of phosphorylation | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | heart process | positive regulation of blood circulation | cellular response to glucose stimulus | developmental process involved in reproduction | negative regulation of muscle contraction | ovarian follicle development | positive regulation of apoptotic process | regulation of localization | response to isoquinoline alkaloid | regulation of the force of heart contraction by chemical signal | gonad development | regulation of programmed cell death | female gonad development | peptidyl-amino acid modification | establishment of localization | negative regulation of cellular process | positive regulation of fibroblast proliferation | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | glucose homeostasis | cellular response to ether | response to antibiotic | positive regulation of sensory perception of pain | positive regulation of vascular smooth muscle cell proliferation | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | regulation of catecholamine secretion | response to morphine | regulation of glucose import | regulation of cytokine biosynthetic process | localization | cellular homeostasis | positive regulation of synaptic transmission | negative regulation of signaling | negative regulation of peptidyl-serine phosphorylation | reproductive system development | multicellular organismal reproductive process | macromolecule localization | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | positive regulation of muscle cell apoptotic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of neurological system process | interspecies interaction between organisms | positive regulation of vasoconstriction | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | heart contraction | response to ether | cellular response to organonitrogen compound | entry into host cell | viral life cycle | development of primary sexual characteristics | muscle contraction | response to stimulus | peptidyl-threonine phosphorylation | negative regulation of peptidyl-threonine phosphorylation | positive regulation of protein metabolic process | regulation of blood vessel size | response to stress | regulation of cell proliferation | ovulation cycle | regulation of blood circulation | negative regulation of glucose transmembrane transport | protein localization to nucleus | response to glucose | protein serine/threonine kinase activity | development of primary female sexual characteristics | positive regulation of cytokine biosynthetic process | reproduction | cellular localization | response to alcohol | rhythmic process | maintenance of protein localization in organelle | negative regulation of transport | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | protein modification process | modulation of chemical synaptic transmission | macromolecule modification | negative regulation of transmembrane transport | response to rapamycin | regulation of membrane potential | response to nitrogen compound | system development | G-protein coupled receptor kinase activity | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | modulation of excitatory postsynaptic potential | negative regulation of phosphate metabolic process | cellular response to antibiotic | multicellular organism development | cellular glucose homeostasis | phosphorus metabolic process | tachykinin receptor signaling pathway | positive regulation of catecholamine secretion | regulation of muscle contraction | negative regulation of glucose import | regulation of phosphorylation | regulation of sensory perception of pain | viral entry into host cell | positive regulation of secretion | response to ketone | viral genome replication | positive regulation of cellular metabolic process | response to ammonium ion | regulation of nitrogen compound metabolic process | regulation of interleukin-6 biosynthetic process | vesicle-mediated transport | response to oxidative stress | regulation of the force of heart contraction | protein localization to organelle | regulation of cellular protein metabolic process | phosphorylation | cellular response to rapamycin | response to toxic substance | response to xenobiotic stimulus | regulation of heart contraction | protein phosphorylation | phosphate-containing compound metabolic process | ovulation cycle process | cellular response to drug | regulation of striated muscle contraction | maintenance of protein location | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | receptor internalization | response to catecholamine | regulation of protein metabolic process | positive regulation of signal transduction | heart development | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | regulation of protein phosphorylation | regulation of tube size | positive regulation of transport | striated muscle contraction | viral process | negative adaptation of signaling pathway | multicellular organism reproduction | response to monoamine | protein metabolic process | regulation of fibroblast proliferation | response to organic substance | follicle-stimulating hormone signaling pathway | beta-adrenergic receptor kinase activity | response to antineoplastic agent | import into cell | anatomical structure development | regulation of vasoconstriction | metabolic process | negative regulation of programmed cell death | regulation of tube diameter | cellular protein localization | cellular response to carbohydrate stimulus | negative regulation of heart contraction | chemical homeostasis | endocytosis | regulation of secretion | positive regulation of cell death | positive regulation of interleukin-6 production | protein kinase activity | organic substance metabolic process | regulation of glucose transmembrane transport | animal organ development | response to reactive oxygen species | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | desensitization of G-protein coupled receptor protein signaling pathway | maintenance of protein location in cell | regulation of phosphate metabolic process | response to alkaloid | positive regulation of cytokine production | positive regulation of excitatory postsynaptic potential | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | negative regulation of the force of heart contraction by chemical signal | protein localization | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule localization | reproductive structure development | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | kinase activity | developmental process | peptidyl-serine phosphorylation | cellular protein modification process | regulation of transport | receptor metabolic process | response to organonitrogen compound | positive regulation of interleukin-6 biosynthetic process | response to anesthetic | positive regulation of metabolic process | cardiac muscle contraction | cellular metabolic process | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | negative regulation of striated muscle contraction | regulation of smooth muscle cell proliferation | response to carbohydrate | negative regulation of cell death | regulation of interleukin-6 production | circulatory system development | aging | carbohydrate homeostasis | muscle system process | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | apical plasma membrane | neuron projection | somatodendritic compartment | cell | cytoplasm | intracellular organelle | membrane microdomain | dendritic tree | apical part of cell | cell projection | neuron spine | postsynapse | plasma membrane | membrane raft | membrane-bounded organelle | dendritic shaft | nucleus | organelle | cell periphery | axon | basolateral plasma membrane | plasma membrane raft | cytosol | intracellular | caveola | membrane
