QuickView for GSN;jsessionid=A178B88D54B53E0053841E0A2BCD8822;jsessionid=51FBC2E8503FD6E0B141158A38E7CAB0;jsessionid=5B4CEE2060905831CD212ED9A6C360FE (gene)
- Gene Symbol:
- Gsn
Rattus norvegicus - Full name:
- gelsolin
- Synonyms:
- gelsolin, ADF, actin-depolymerizing factor, brevin
- Genomic Location:
- Chr 3: 14360245-14386313
- Description:
-
plays a role in phosphoinositide mediated disassembly of actin filaments in Sertoli cell adhesion complexes; may regulate sperm release and turnover of the blood-testis barrier
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
P300_01 , HSF1_01 , AP1FJ_Q2 , AP1_Q2 , AP1_Q4 , RFX1_01 , STAT5A_02 , HSF_Q6 , NFAT_Q4_01 , RGAANNTTC_HSF1_01
GO Molecular Function
actin binding | actin filament binding | cation binding | protein-containing complex binding | myosin binding | cytoskeletal protein binding | ion binding | myosin II binding | protein binding | calcium ion binding | metal ion binding
GO Biological Process
response to extracellular stimulus | regulation of supramolecular fiber organization | regulation of cysteine-type endopeptidase activity | response to nutrient levels | actin filament-based process | extracellular structure organization | response to cytokine | positive regulation of cellular component organization | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | phagocytosis, engulfment | regulation of localization | regulation of programmed cell death | negative regulation of protein complex disassembly | actin cytoskeleton organization | epithelial cell apoptotic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | response to metal ion | regulation of protein localization to membrane | cell differentiation | defense response | nervous system development | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | response to drug | actin nucleation | neurogenesis | regulation of organelle organization | regulation of actin polymerization or depolymerization | striated muscle atrophy | membrane organization | response to antibiotic | response to folic acid | cellular process | positive regulation of actin filament polymerization | localization | developmental growth | negative regulation of viral life cycle | macromolecule localization | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | positive regulation of epithelial cell apoptotic process | tissue development | regeneration | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | cellular component organization | regulation of establishment of cell polarity | cellular response to metal ion | cellular response to interferon-gamma | regulation of actin filament length | positive regulation of protein processing | response to stimulus | positive regulation of protein processing in phagocytic vesicle | regulation of cellular protein localization | oligodendrocyte development | actin filament reorganization | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | positive regulation of cysteine-type endopeptidase activity | programmed cell death | protein destabilization | phosphatidylinositol-mediated signaling | supramolecular fiber organization | cellular response to inorganic substance | cellular localization | response to alcohol | cellular response to cadmium ion | positive regulation of proteolysis | actin filament polymerization | extracellular matrix organization | regulation of cellular component size | cellular component assembly | actin filament severing | regulation of protein processing | regulation of cell adhesion | positive regulation of actin nucleation | regulation of establishment or maintenance of cell polarity | response to ethanol | actin filament capping | response to nitrogen compound | apoptotic process | organelle assembly | system development | regulation of viral entry into host cell | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | regulation of actin cytoskeleton organization | multicellular organism development | regulation of peptidase activity | regulation of actin filament organization | actin filament organization | regulation of catalytic activity | amyloid fibril formation | regulation of protein complex disassembly | wound healing | regulation of T cell activation | regulation of gene expression | cell projection assembly | positive regulation of cellular metabolic process | regulation of lymphocyte activation | negative regulation of actin filament polymerization | regulation of nitrogen compound metabolic process | actin polymerization or depolymerization | regulation of cysteine-type endopeptidase activity involved in apoptotic process | renal absorption | protein polymerization | positive regulation of protein complex assembly | vesicle-mediated transport | response to nutrient | positive regulation of hydrolase activity | negative regulation of viral process | regulation of receptor clustering | cellular response to cytokine stimulus | response to cadmium ion | positive regulation of keratinocyte apoptotic process | regulation of cellular protein metabolic process | glial cell differentiation | hepatocyte apoptotic process | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | inositol lipid-mediated signaling | response to toxic substance | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of plasma membrane raft polarization | maintenance of protein location | cell communication | regulation of cellular metabolic process | regulation of actin filament polymerization | regulation of actin filament depolymerization | regulation of keratinocyte apoptotic process | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | regulation of viral process | regulation of protein depolymerization | positive regulation of molecular function | protein-containing complex assembly | regulation of podosome assembly | protein metabolic process | negative regulation of protein polymerization | response to organic substance | negative regulation of viral entry into host cell | response to wounding | import into cell | anatomical structure development | cell projection organization | metabolic process | positive regulation of supramolecular fiber organization | negative regulation of cytoskeleton organization | cellular protein localization | oligodendrocyte differentiation | membrane invagination | actin cytoskeleton reorganization | endocytosis | positive regulation of cell death | immune response | regulation of actin nucleation | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | response to vitamin | cilium assembly | regulation of cell activation | muscle atrophy | positive regulation of programmed cell death | maintenance of protein location in cell | barbed-end actin filament capping | cytoskeleton organization | renal system process | response to interferon-gamma | cilium organization | negative regulation of actin filament depolymerization | regulation of cell communication | positive regulation of protein maturation | signaling | glial cell development | response to organic cyclic compound | cell development | protein localization | regulation of endopeptidase activity | cellular macromolecule localization | developmental process | organelle organization | sequestering of actin monomers | innate immune response | positive regulation of protein polymerization | response to organonitrogen compound | negative regulation of supramolecular fiber organization | central nervous system development | positive regulation of metabolic process | regulation of actin filament-based process | immune system process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of organelle assembly | regulation of viral life cycle | aging | tissue regeneration | phagocytosis | extracellular matrix disassembly | regulation of cellular component organization | regulation of establishment of T cell polarity | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | renal protein absorption
GO Cellular Component
intracellular membrane-bounded organelle | ruffle | adherens junction | focal adhesion | cytoplasmic vesicle | cell | lamellipodium | cytoplasm | cortical cytoskeleton | cell-substrate junction | intracellular organelle | actin cytoskeleton | protein-containing complex | cell projection | plasma membrane | cell leading edge | vesicle | podosome | perinuclear region of cytoplasm | cytoplasmic region | actin cap | cortical actin cytoskeleton | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | sarcoplasm | extracellular space | cell periphery | cell-substrate adherens junction | cytosol | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | cell junction | myelin sheath | membrane | phagocytic vesicle
