QuickView for GUCA2B;jsessionid=506753D54F80E5E4B09BFCB87441E01B;jsessionid=84A2CC8486C41BF3F264F443255424EA (gene)

Gene Symbol:

Guca2b Mus musculus

Full name:

guanylate cyclase activator 2b (retina)

Synonyms:

AV066530, Gcap2, Ugn, guanylate cyclase activator 2B, granule cell antiserum positive 2, uroguanylin

Genomic Location:

Chr 4: 119329220-119331550

Description:

This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice ...

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This gene encodes a member of the guanylin family and preproprotein that is proteolytically processed to generate a mature protein product. The mature protein product, known as uroguanylin, is an endogenous ligand for the guanylate cyclase-C receptor and may regulate salt and water homeostasis in the intestine and kidneys. Homozygous knockout mice for this gene exhibit impaired sodium chloride excretion and elevated arterial pressure. This gene is present in a gene cluster with a related guanylin family member on chromosome 4.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CP2_01 ,  HNF1_01 ,  HNF1_C ,  PAX4_03 ,  SREBP1_Q6 ,  SREBP_Q3 ,  HNF1_Q6 ,  MYB_Q5_01 ,  RYTAAWNNNTGAY_UNKNOWN ,  GGGTGGRR_PAX4_03

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