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QuickView for Gpa1;jsessionid=7CF2DE37631D3FA4D23A17EB5D7EAC64;jsessionid=801B6AF0BA1BC791196809072537BFA6 (gene)


Gene Symbol:
GNAI2 Homo sapiens Homo sapiens
Full name:
G protein subunit alpha i2
Synonyms:
GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1, guanine nucleotide-binding protein G(i) subunit alpha-2, GTP-binding regulatory protein Gi alpha-2 chain, adenylate cyclase-inhibiting G alpha protein, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, guanine nucleotide-binding protein G(i), alpha-2 subunit
Genomic Location:
Chr 3: 50248651-50271790
Description:
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3p21.31





GO Molecular Function

guanyl ribonucleotide binding | ribonucleoside binding | cation binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | G-protein beta/gamma-subunit complex binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | G-protein coupled receptor binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | negative regulation of G-protein coupled receptor protein signaling pathway | regulation of ERK1 and ERK2 cascade | positive regulation of locomotion | regulation of dephosphorylation | response to nutrient levels | intracellular signal transduction | regulation of localization | regulation of programmed cell death | response to hormone | negative regulation of cellular process | regulation of phosphatase activity | response to drug | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | regulation of renal sodium excretion | positive regulation of vascular smooth muscle cell proliferation | cellular process | gamma-aminobutyric acid signaling pathway | regulation of cell motility | acetylcholine receptor signaling pathway | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | regulation of metabolic process | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | positive regulation of renal sodium excretion | regulation of urine volume | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | negative regulation of lyase activity | response to stimulus | positive regulation of NAD(P)H oxidase activity | regulation of excretion | positive regulation of protein metabolic process | regulation of cell proliferation | positive regulation of superoxide anion generation | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway | negative regulation of transport | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | modulation of chemical synaptic transmission | response to nitrogen compound | cellular response to hormone stimulus | regulation of superoxide metabolic process | regulation of signal transduction | positive regulation of urine volume | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | regulation of MAPK cascade | G-protein coupled acetylcholine receptor signaling pathway | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | regulation of phosphorylation | cellular response to ammonium ion | positive regulation of secretion | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | response to ammonium ion | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | response to acetylcholine | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | regulation of cellular component movement | response to nutrient | second-messenger-mediated signaling | positive regulation of cell migration | cell proliferation | cell division | regulation of cellular protein metabolic process | negative regulation of adenylate cyclase activity | regulation of apoptotic signaling pathway | regulation of cyclase activity | positive regulation of cellular response to insulin stimulus | cellular response to drug | negative regulation of protein dephosphorylation | cell communication | regulation of cellular metabolic process | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | positive regulation of transport | positive regulation of molecular function | negative regulation of exocytosis | positive regulation of protein modification process | response to organic substance | cAMP-mediated signaling | regulation of protein dephosphorylation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | cell surface receptor signaling pathway | regulation of neural precursor cell proliferation | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of body fluid levels | negative regulation of programmed cell death | regulation of vesicle-mediated transport | regulation of secretion | negative regulation of protein tyrosine phosphatase activity | protein folding | adenosine receptor signaling pathway | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | positive regulation of ERK1 and ERK2 cascade | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | renal system process | regulation of regulated secretory pathway | positive regulation of MAPK cascade | regulation of adenylate cyclase activity | negative regulation of protein metabolic process | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of oxidoreductase activity | positive regulation of phosphorylation | negative regulation of phosphoprotein phosphatase activity | regulation of ion transport | negative regulation of calcium ion-dependent exocytosis | regulation of G-protein coupled receptor protein signaling pathway | positive regulation of neural precursor cell proliferation | regulation of phosphoprotein phosphatase activity | regulation of NAD(P)H oxidase activity | negative regulation of cAMP-mediated signaling | regulation of calcium ion transport | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of superoxide anion generation | negative regulation of dephosphorylation | negative regulation of hydrolase activity | negative regulation of synaptic transmission | regulation of calcium ion-dependent exocytosis | positive regulation of metabolic process | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

heterotrimeric G-protein complex | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | catalytic complex | neuron projection | extrinsic component of membrane | somatodendritic compartment | microtubule organizing center | cell body | cell | cytoplasmic side of membrane | nuclear lumen | plasma membrane protein complex | extrinsic component of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | dendritic tree | centrosome | protein-containing complex | cell projection | nucleoplasm | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | midbody | membrane raft | vesicle | extracellular exosome | microtubule cytoskeleton | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane