QuickView for HCK;jsessionid=82F326A8ACB623A791CE053CFB1D057C;jsessionid=946D2C22B6C90513635E2A92EAD963A7;jsessionid=5F23F9B70A17CBC0CBE02DB456D1E31B (gene)
- Gene Symbol:
- Hck
Mus musculus - Full name:
- hemopoietic cell kinase
- Synonyms:
- AI849071, Bmk, tyrosine-protein kinase HCK, B cell/myeloid kinase, hematopoietic cell kinase, p56-HCK/p59-HCK
- Genomic Location:
- Chr 2: 152934244-152977172
- Description:
-
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, res...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein phosphorylated amino acid binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
exocytosis | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | defense response to other organism | establishment of localization | regulation of cell shape | negative regulation of cellular process | cell differentiation | defense response | peptidyl-tyrosine phosphorylation | regulation of organelle organization | cellular process | secretion | localization | negative regulation of apoptotic process | peptidyl-tyrosine autophosphorylation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of protein complex assembly | response to stimulus | response to stress | regulation of cell proliferation | secretion by cell | regulation of phagocytosis | protein modification process | regulation of actin cytoskeleton reorganization | macromolecule modification | regulation of nucleic acid-templated transcription | response to external biotic stimulus | nitrogen compound metabolic process | positive regulation of organelle organization | regulation of actin cytoskeleton organization | phosphorus metabolic process | regulation of gene expression | positive regulation of actin cytoskeleton reorganization | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | vesicle-mediated transport | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | response to bacterium | cell communication | regulation of cellular metabolic process | inflammatory response | positive regulation of cytoskeleton organization | defense response to bacterium | positive regulation of cell proliferation | regulation of RNA metabolic process | protein tyrosine kinase activity | regulation of podosome assembly | protein metabolic process | import into cell | regulation of DNA-binding transcription factor activity | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of vesicle-mediated transport | endocytosis | protein kinase activity | organic substance metabolic process | defense response to Gram-positive bacterium | non-membrane spanning protein tyrosine kinase activity | signaling | regulation of transcription, DNA-templated | regulation of endocytosis | cellular protein metabolic process | response to biotic stimulus | regulation of developmental process | kinase activity | developmental process | cellular protein modification process | regulation of transport | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of actin filament-based process | immune system process | cellular metabolic process | regulation of cell death | regulation of organelle assembly | negative regulation of cell death | phagocytosis | regulation of cellular component organization | regulation of cytoskeleton organization | response to other organism | signal transduction | macromolecule metabolic process
GO Cellular Component
supramolecular fiber | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | extrinsic component of membrane | adherens junction | focal adhesion | cytoplasmic vesicle | cell | cytoplasmic side of membrane | nuclear lumen | extrinsic component of plasma membrane | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | membrane microdomain | Golgi apparatus | cell projection | endomembrane system | nucleoplasm | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | membrane raft | vacuole | vesicle | lytic vacuole | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | plasma membrane raft | intracellular vesicle | actin filament | cytoskeleton | intracellular | cell junction | caveola | membrane | supramolecular complex
