QuickView for HDGFRP2;jsessionid=76EA3B102C936B3FB4AB6975B62D2308;jsessionid=AA5D054A6361AC67A6590F4F456BA2B2;jsessionid=48E8E98FADCA505E6B527496657BBE1F (gene)

Gene Symbol:

HDGFL2 Homo sapiens

Full name:

HDGF like 2

Synonyms:

HDGF-2, HDGF2, HDGFRP2, HRP-2, HRP2, hepatoma-derived growth factor-related protein 2

Genomic Location:

Chr 19: 4423255-4453223

Description:

This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p7...

View Full Description

This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Cytogenetic Map:

19p13.3

search → result