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QuickView for HSC5;jsessionid=D3CCEA46C59EC669DCB0C7FE1CFF4281;jsessionid=5D04161C5EEB44062C9A6FF1FDC3A850 (gene)


Gene Symbol:
HSPA9 Homo sapiens Homo sapiens
Full name:
heat shock protein family A (Hsp70) member 9
Synonyms:
CRP40, CSA, EVPLS, GRP-75, GRP75, HEL-S-124m, HSPA9B, MOT, MOT2, MTHSP75, PBP74, SAAN, SIDBA4, stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, catecholamine-regulated protein 40, epididymis secretory sperm binding protein Li 124m, heat shock 70kD protein 9B, heat shock 70kDa protein 9 (mortalin), mortalin, perinuclear, mortalin-2, mortalin2, p66-mortalin, peptide-binding protein 74
Genomic Location:
Chr 5: 137918923-137939014
Description:
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance o...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 5
5q31.2


Transcripts Names
NM_004134



GO Molecular Function

enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | protein binding involved in protein folding | purine ribonucleoside triphosphate binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding

GO Biological Process

negative regulation of immune system process | negative regulation of hematopoietic progenitor cell differentiation | response to cytokine | 'de novo' posttranslational protein folding | nuclear export | sulfur compound metabolic process | regulation of programmed cell death | erythrocyte homeostasis | establishment of localization | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | negative regulation of hematopoietic stem cell differentiation | cell differentiation | regulation of hematopoietic progenitor cell differentiation | intracellular transport | cellular process | localization | chaperone-mediated protein folding | protein transport | immune system development | macromolecule localization | negative regulation of apoptotic process | regulation of myeloid cell differentiation | establishment of localization in cell | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | cellular response to unfolded protein | response to topologically incorrect protein | cellular component organization | cellular response to topologically incorrect protein | protein export from nucleus | response to stimulus | negative regulation of erythrocyte differentiation | iron-sulfur cluster assembly | response to stress | intracellular protein transport | cellular localization | response to temperature stimulus | cofactor metabolic process | hemopoiesis | cellular component assembly | negative regulation of hemopoiesis | response to interleukin-12 | interleukin-12-mediated signaling pathway | myeloid cell homeostasis | system development | multicellular organism development | regulation of hematopoietic stem cell differentiation | organic substance transport | cellular response to stress | cellular response to heat | negative regulation of myeloid cell differentiation | peptide transport | cytokine-mediated signaling pathway | homeostasis of number of cells | cellular response to cytokine stimulus | 'de novo' protein folding | cell communication | protein binding involved in protein folding | homeostatic process | regulation of stem cell differentiation | response to organic substance | regulation of hemopoiesis | anatomical structure development | cell surface receptor signaling pathway | metabolic process | negative regulation of programmed cell death | cellular protein localization | regulation of erythrocyte differentiation | amide transport | protein folding | nuclear transport | animal organ development | response to heat | negative regulation of stem cell differentiation | establishment of protein localization | signaling | protein localization | response to unfolded protein | cellular macromolecule localization | nucleocytoplasmic transport | chaperone cofactor-dependent protein refolding | regulation of developmental process | developmental process | erythrocyte differentiation | protein refolding | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of cell death | negative regulation of cell differentiation | signal transduction | multicellular organismal process

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | adherens junction | focal adhesion | cell | nuclear lumen | nucleolus | mitochondrial nucleoid | cytoplasm | nucleoid | cell-substrate junction | intracellular organelle | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cell-substrate adherens junction | intracellular | cell junction | myelin sheath