QuickView for Hank;jsessionid=2841C7831B85927CCFFCE88940EFE6F4;jsessionid=FBE142C096BD7F2AB4C18F8332A856E7;jsessionid=A6872E85DB85C3067FB72C55AA3233A4;jsessionid=68CDFE4CCC602A0EEB2A03C205834828 (gene)

Gene Symbol:

ANKH Homo sapiens

Full name:

ANKH inorganic pyrophosphate transport regulator

Synonyms:

ANK, CCAL2, CMDJ, CPPDD, HANK, MANK, SLC62A1, progressive ankylosis protein homolog, ankylosis, progressive homolog

Genomic Location:

Chr 5: 14762019-14924876

Description:

This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations ...

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This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FAC1_01 ,  EGR2_01 ,  WHN_B ,  CREB_Q3 ,  NKX62_Q2 ,  ZID_01 ,  GGCNRNWCTTYS_UNKNOWN ,  CTTTAAR_UNKNOWN ,  ELK1_01 ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  ACAWYAAAG_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-203

Cytogenetic Map:

5p15.2

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