QuickView for Hspa5;jsessionid=C1144D6B1B9207F271A23997F1BA1607 (gene)
- Gene Symbol:
- Hspa5
Rattus norvegicus - Full name:
- heat shock protein family A member 5
- Synonyms:
- BIP, GRP 78, GRP78, 78 kDa glucose-regulated protein, GRP-78, heat shock 70 kDa protein 5, heat shock 70kD protein 5, heat shock 70kDa protein 5 (glucose-regulated protein), heat shock protein 5, immunoglobulin heavy chain-binding protein, steroidogenesis-activator polypeptide
- Genomic Location:
- Chr 3: 13783825-13788022
- Description:
-
secreted protein of the endoplasmic reticulum; may be involved in the assembly of secreted and membrane-bound proteins
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | catalytic activity | ribonucleoprotein complex binding | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | ribosome binding | protein binding involved in protein folding | purine ribonucleoside triphosphate binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
response to extracellular stimulus | brain development | response to radiation | regulation of IRE1-mediated unfolded protein response | cellular response to glucose starvation | positive regulation of locomotion | response to nutrient levels | response to endoplasmic reticulum stress | response to cytokine | positive regulation of cellular component organization | regulation of neurogenesis | 'de novo' posttranslational protein folding | regulation of endoplasmic reticulum unfolded protein response | proteolysis | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | regulation of transforming growth factor beta receptor signaling pathway | neuron death | negative regulation of cellular process | negative regulation of IRE1-mediated unfolded protein response | positive regulation of developmental process | response to metal ion | cell differentiation | nervous system development | cellular response to extracellular stimulus | response to drug | cerebellum morphogenesis | neurogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | response to organophosphorus | response to methamphetamine hydrochloride | cellular process | organic substance catabolic process | regulation of cell motility | localization | negative regulation of protein homodimerization activity | proteolysis involved in cellular protein catabolic process | chaperone-mediated protein folding | negative regulation of signaling | protein localization to endoplasmic reticulum | macromolecule localization | endoplasmic reticulum unfolded protein response | negative regulation of response to endoplasmic reticulum stress | negative regulation of apoptotic process | cellular response to starvation | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | regulation of binding | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | response to nerve growth factor | positive regulation of cellular protein metabolic process | cellular response to unfolded protein | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular response to topologically incorrect protein | cellular response to metal ion | anatomical structure arrangement | head development | response to stimulus | metencephalon development | positive regulation of protein metabolic process | response to cocaine | response to stress | regulation of response to endoplasmic reticulum stress | toxin transport | regulation of protein ubiquitination | response to starvation | regulation of protein homodimerization activity | programmed cell death | cellular response to inorganic substance | cellular protein catabolic process | cellular localization | response to temperature stimulus | proteasomal protein catabolic process | maintenance of protein localization in organelle | negative regulation of endoplasmic reticulum unfolded protein response | cellular response to organic cyclic compound | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | cellular response to antibiotic | multicellular organism development | response to purine-containing compound | cerebellum development | cellular response to nerve growth factor stimulus | ER-nucleus signaling pathway | regulation of neuron differentiation | cellular response to stress | protein catabolic process | stress response to metal ion | cellular response to heat | positive regulation of cellular metabolic process | cellular response to radiation | response to manganese ion | response to ammonium ion | regulation of nitrogen compound metabolic process | regulation of cell migration | neuron apoptotic process | positive regulation of cell projection organization | negative regulation of cellular response to growth factor stimulus | regulation of cellular component movement | cellular response to gamma radiation | protein localization to organelle | negative regulation of binding | positive regulation of cell differentiation | positive regulation of cell migration | cellular response to cytokine stimulus | 'de novo' protein folding | regulation of cellular protein metabolic process | hindbrain development | response to xenobiotic stimulus | response to gamma radiation | cellular response to drug | maintenance of protein location | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein metabolic process | protein binding involved in protein folding | regulation of locomotion | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | ER overload response | ERAD pathway | neuron differentiation | cellular response to interleukin-4 | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | cellular response to calcium ion | response to organic substance | cellular macromolecule catabolic process | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | negative regulation of programmed cell death | cellular protein localization | cerebellar cortex development | hindbrain morphogenesis | organic substance metabolic process | protein folding | cell death | cerebellar Purkinje cell layer development | maintenance of protein localization in endoplasmic reticulum | animal organ development | cerebellum structural organization | response to heat | cellular response to ionizing radiation | maintenance of protein location in cell | cellular response to cAMP | response to alkaloid | hindbrain structural organization | response to cAMP | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of protein binding | response to organic cyclic compound | protein localization | cellular protein metabolic process | response to unfolded protein | anatomical structure morphogenesis | cellular macromolecule localization | response to biotic stimulus | chaperone cofactor-dependent protein refolding | regulation of nervous system development | regulation of developmental process | developmental process | response to salt | cellular response to manganese ion | response to organonitrogen compound | protein refolding | response to calcium ion | central nervous system development | ubiquitin-dependent ERAD pathway | response to anesthetic | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | modification-dependent protein catabolic process | negative regulation of cell death | positive regulation of protein ubiquitination | regulation of cellular component organization | response to ionizing radiation | signal transduction | regulation of signaling | cellular response to growth factor stimulus | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | response to interleukin-4
GO Cellular Component
endoplasmic reticulum chaperone complex | endoplasmic reticulum-Golgi intermediate compartment | integral component of membrane | intracellular membrane-bounded organelle | COP9 signalosome | cell | integral component of endoplasmic reticulum membrane | smooth endoplasmic reticulum | intrinsic component of membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | plasma membrane | midbody | endoplasmic reticulum lumen | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cell surface | intracellular | myelin sheath | membrane
