QuickView for IFNAR2;jsessionid=D8162E65A7636FD2044C30F4D635C40B;jsessionid=0BD24C51D0AE76F9465186B92C978C97;jsessionid=A4600954C9A92E3AB896D5F70D1E237C;jsessionid=9EA748F8E2E657B048A71337F3FD546D (gene)
- Gene Symbol:
- IFNAR2
Homo sapiens - Full name:
- interferon alpha and beta receptor subunit 2
- Synonyms:
- IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha/beta receptor 2, IFN-R-2, IFN-alpha/beta receptor 2, human interferon alpha/beta receptor, interferon (alpha, beta and omega) receptor 2, interferon alpha binding protein, interferon receptor, interferon-alpha/beta receptor beta chain, type I interferon receptor 2
- Genomic Location:
- Chr 21: 33524101-33558697
- Description:
-
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different is...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
21q22.11
GO Molecular Function
kinase binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | signaling receptor activity | type I interferon receptor activity | interferon receptor activity | cytokine receptor activity | protein binding
GO Biological Process
response to virus | response to cytokine | intracellular signal transduction | cellular response to type I interferon | defense response to other organism | regulation of immune system process | JAK-STAT cascade | defense response | cellular process | response to type I interferon | regulation of response to cytokine stimulus | regulation of immune response | regulation of cellular process | response to stimulus | response to stress | response to interferon-beta | response to external biotic stimulus | regulation of signal transduction | defense response to virus | cytokine-mediated signaling pathway | response to interferon-alpha | cellular response to cytokine stimulus | type I interferon receptor activity | interferon receptor activity | cytokine receptor activity | cell communication | regulation of cytokine-mediated signaling pathway | response to organic substance | regulation of innate immune response | cell surface receptor signaling pathway | immune response | regulation of type I interferon-mediated signaling pathway | type I interferon signaling pathway | regulation of cell communication | signaling | response to biotic stimulus | innate immune response | immune system process | cellular response to organic substance | response to other organism | signal transduction | regulation of signaling
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | plasma membrane | integral component of plasma membrane | extracellular region | cell periphery | intracellular | membrane | intrinsic component of plasma membrane
