QuickView for IGF-I;jsessionid=E15DF64F0316FAF0B3FFED7594F601BB (gene)

GO Molecular Function

protein kinase activator activity | protein serine/threonine kinase activator activity | enzyme activator activity | protein kinase regulator activity | kinase regulator activity | protein-containing complex binding | lipid binding | signaling receptor binding | hormone activity | molecular function regulator | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | protein binding | insulin receptor binding | receptor regulator activity | kinase activator activity | growth factor activity | receptor ligand activity | insulin-like growth factor receptor binding | enzyme regulator activity | steroid binding

GO Biological Process

positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | negative regulation of smooth muscle cell apoptotic process | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of glycogen biosynthetic process | positive regulation of striated muscle cell differentiation | positive regulation of hormone biosynthetic process | regulation of muscle system process | regulation of cell cycle process | protein kinase activator activity | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | regulation of intracellular protein transport | protein serine/threonine kinase activator activity | response to nutrient levels | negative regulation of MAPK cascade | negative regulation of immune system process | positive regulation of Ras protein signal transduction | detection of stimulus | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of neurogenesis | response to lipopolysaccharide | cranial skeletal system development | developmental process involved in reproduction | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | enzyme activator activity | regulation of cell development | protein stabilization | regulation of localization | cellular response to progesterone stimulus | prostate gland growth | protein kinase regulator activity | morphogenesis of an epithelium | positive regulation of steroid hormone biosynthetic process | positive regulation of striated muscle tissue development | positive regulation of embryonic development | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of oogenesis | regulation of cardiac muscle cell differentiation | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of cysteine-type endopeptidase activity | regulation of immune system process | response to hormone | cellular response to Thyroglobulin triiodothyronine | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | response to dexamethasone | positive regulation of lymphocyte activation | bone development | regulation of heart growth | regulation of protein import | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | bone mineralization | respiratory tube development | detection of mechanical stimulus involved in sensory perception | type I pneumocyte differentiation | striated muscle cell development | nervous system development | negative regulation of mitochondrion organization | response to growth hormone | negative regulation of oligodendrocyte apoptotic process | response to drug | multicellular organism growth | organ growth | negative regulation of protein phosphorylation | cellular chemical homeostasis | neurogenesis | glucose homeostasis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | response to antibiotic | sensory perception of mechanical stimulus | negative regulation of proteolysis | positive regulation of vascular smooth muscle cell proliferation | regulation of neuron death | regulation of oocyte development | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | regulation of glucose import | regulation of cell motility | cellular homeostasis | regulation of steroid hormone biosynthetic process | regulation of glycolytic process | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | regulation of calcium-mediated signaling | tissue remodeling | negative regulation of signaling | developmental growth | regulation of cell growth involved in cardiac muscle cell development | myotube cell development | cranial suture morphogenesis | kinase regulator activity | reproductive system development | response to progesterone | response to estradiol | regulation of mitotic nuclear division | regulation of embryonic development | female pregnancy | regulation of striated muscle tissue development | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | lung epithelium development | regulation of multicellular organism growth | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | positive regulation of muscle cell differentiation | muscle structure development | muscle cell differentiation | negative regulation of apoptotic signaling pathway | regeneration | glycoprotein biosynthetic process | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of osteoblast differentiation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | positive regulation of activated T cell proliferation | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | prostate gland epithelium morphogenesis | MAPK cascade | urogenital system development | positive regulation of epithelial cell migration | regulation of peptide secretion | response to Thyroglobulin triiodothyronine | response to stimulus | negative regulation of epithelial cell apoptotic process | positive regulation of vascular endothelial cell proliferation | vasculature development | muscle cell development | lung lobe morphogenesis | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | chondroitin sulfate proteoglycan biosynthetic process | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | blood vessel remodeling | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | positive regulation of phosphatidylinositol 3-kinase signaling | cellular response to xenobiotic stimulus | gland morphogenesis | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of JAK-STAT cascade | positive regulation of cellular protein localization | positive regulation of lymphocyte proliferation | craniofacial suture morphogenesis | posttranscriptional regulation of gene expression | regulation of cell proliferation | negative regulation of oocyte development | positive regulation of lipid biosynthetic process | tube morphogenesis | response to peptide | positive regulation of cell-cell adhesion | positive regulation of glucose import | circadian rhythm | response to glucose | proteoglycan metabolic process | response to starvation | regulation of smooth muscle cell migration | programmed cell death | phosphatidylinositol-mediated signaling | regulation of transcription regulatory region DNA binding | positive regulation of cell activation | reproduction | response to alcohol | cardiovascular system development | response to temperature stimulus | rhythmic process | response to molecule of bacterial origin | cellular response to toxic substance | positive regulation of T cell activation | regulation of DNA binding | positive regulation of blood vessel endothelial cell migration | positive regulation of gliogenesis | cellular response to organic cyclic compound | hormone activity | carbohydrate derivative biosynthetic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | regulation of cell adhesion | regulation of steroid biosynthetic process | cellular biosynthetic process | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | regulation of steroid metabolic process | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | regulation of establishment or maintenance of cell polarity | response to ethanol | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | water homeostasis | detection of abiotic stimulus | regulation of neurotransmitter levels | response to nitrogen compound | lung alveolus development | apoptotic process | protein kinase B signaling | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | response to nicotine | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | response to activity | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | response to purine-containing compound | learning or memory | type II pneumocyte differentiation | mammary gland development | positive regulation of smooth muscle cell migration | positive regulation of muscle organ development | cellular response to insulin stimulus | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of ossification | negative regulation of peptidase activity | wound healing | regulation of T cell activation | positive regulation of cell cycle | regulation of activated T cell proliferation | positive regulation of mitotic cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | pancreas development | positive regulation of secretion | response to ketone | response to lipid | nervous system process | cellular response to peptide | branching involved in prostate gland morphogenesis | positive regulation of intracellular protein transport | exocrine pancreas development | regulation of protein import into nucleus, translocation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of protein localization to nucleus | positive regulation of ATP biosynthetic process | lung secretory cell differentiation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cardiac atrium development | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | response to corticosteroid | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | regulation of smooth muscle cell apoptotic process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell differentiation | regulation of endothelial cell migration | activation of protein kinase B activity | positive regulation of calcium-mediated signaling | negative regulation of extrinsic apoptotic signaling pathway | cognition | positive regulation of steroid metabolic process | positive regulation of cell migration | negative regulation of intracellular steroid hormone receptor signaling pathway | positive regulation of glucose transmembrane transport | positive regulation of glycolytic process | cell proliferation | positive regulation of protein localization to nucleus | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of trophectodermal cell proliferation | positive regulation of T cell proliferation | glial cell differentiation | positive regulation of ossification | cellular response to glucocorticoid stimulus | phosphorylation | inositol lipid-mediated signaling | response to toxic substance | regulation of apoptotic signaling pathway | positive regulation of cell growth involved in cardiac muscle cell development | response to xenobiotic stimulus | regulation of epithelial cell apoptotic process | protein phosphorylation | cellular response to corticosteroid stimulus | phosphate-containing compound metabolic process | sensory organ development | cellular response to drug | regulation of mitochondrion organization | response to bacterium | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | skeletal system morphogenesis | positive regulation of tyrosine phosphorylation of STAT protein | regulation of glial cell proliferation | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | regulation of androgen receptor signaling pathway | heart development | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | bone morphogenesis | regulation of locomotion | lung vasculature development | regulation of RNA metabolic process | positive regulation of transport | chondroitin sulfate proteoglycan metabolic process | regulation of lipid biosynthetic process | striated muscle cell differentiation | negative regulation of cholangiocyte apoptotic process | ossification involved in bone maturation | apoptotic signaling pathway | cellular response to nicotine | regulation of mitotic cell cycle | positive regulation of glial cell proliferation | positive regulation of molecular function | regulation of nucleocytoplasmic transport | positive regulation of osteoblast differentiation | lung epithelial cell differentiation | prostate gland stromal morphogenesis | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | positive regulation of organ growth | protein metabolic process | regulation of fibroblast proliferation | regulation of cardiac muscle hypertrophy | regulation of establishment of protein localization | cellular response to insulin-like growth factor stimulus | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | regulation of protein import into nucleus | digestive system development | regulation of insulin-like growth factor receptor signaling pathway | branching morphogenesis of an epithelial tube | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | response to antineoplastic agent | response to mechanical stimulus | detection of stimulus involved in sensory perception | positive regulation of steroid biosynthetic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | response to insulin | positive regulation of myoblast proliferation | anatomical structure development | kinase activator activity | cell surface receptor signaling pathway | positive regulation of neurogenesis | positive regulation of small GTPase mediated signal transduction | regulation of glucose metabolic process | growth factor activity | regulation of neural precursor cell proliferation | metabolic process | positive regulation of cell development | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | developmental maturation | negative regulation of programmed cell death | regulation of myoblast proliferation | ear development | cellular response to carbohydrate stimulus | negative regulation of muscle cell apoptotic process | negative regulation of vascular associated smooth muscle cell apoptotic process | chemical homeostasis | regulation of secretion | behavior | receptor ligand activity | response to caffeine | organic substance metabolic process | connective tissue development | maintenance of cell number | cell death | negative regulation of gene expression | regulation of glucose transmembrane transport | animal organ development | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | regulation of cell activation | regulation of protein secretion | positive regulation of kinase activity | regulation of calcineurin-NFAT signaling cascade | response to heat | regulation of striated muscle cell differentiation | regulation of ATP metabolic process | regulation of phosphate metabolic process | biomineral tissue development | response to alkaloid | cellular response to steroid hormone stimulus | prostate gland morphogenesis | positive regulation of binding | detection of mechanical stimulus | positive regulation of muscle tissue development | positive regulation of glycoprotein metabolic process | positive regulation of calcineurin-NFAT signaling cascade | positive regulation of intracellular transport | positive regulation of endothelial cell migration | negative regulation of glial cell apoptotic process | cell activation | positive regulation of MAPK cascade | lung development | cellular response to dexamethasone stimulus | response to epidermal growth factor | morphogenesis of a branching epithelium | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | memory | negative regulation of protein metabolic process | sensory perception | regulation of epithelial cell migration | positive regulation of carbohydrate metabolic process | skeletal muscle tissue regeneration | positive regulation of cardiac muscle cell differentiation | bone maturation | negative regulation of androgen receptor signaling pathway | cellular response to estradiol stimulus | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | positive regulation of protein import into nucleus, translocation | regulation of cell communication | regulation of blood vessel endothelial cell migration | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | response to amyloid-beta | regulation of transcription, DNA-templated | myotube differentiation | response to organic cyclic compound | myoblast differentiation | cell development | positive regulation of DNA binding | negative regulation of peptidyl-tyrosine phosphorylation | regulation of developmental growth | regulation of T cell proliferation | regulation of epithelial cell proliferation | extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of Ras protein signal transduction | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | positive regulation of MAP kinase activity | positive regulation of protein import into nucleus | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | response to biotic stimulus | reproductive structure development | regulation of nervous system development | regulation of developmental process | regulation of ion transport | positive regulation of neural precursor cell proliferation | developmental process | regulation of muscle cell differentiation | positive regulation of protein import | lung cell differentiation | positive regulation of cell cycle process | regulation of cell growth | regulation of calcium ion transport | response to thyroid hormone | cellular protein modification process | tube development | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | response to organonitrogen compound | lung morphogenesis | regulation of glycogen biosynthetic process | epithelial cell differentiation | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | cellular response to electrical stimulus | cardiac chamber development | response to electrical stimulus | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | ossification | osteoblast differentiation | positive regulation of lipid metabolic process | myoblast proliferation | positive regulation of cerebellar granule cell precursor proliferation | skeletal system development | lung lobe development | cellular metabolic process | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | positive regulation of cardiac muscle tissue development | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | regulation of translation | negative regulation of cell death | bone mineralization involved in bone maturation | negative regulation of cell development | circulatory system development | positive regulation of insulin-like growth factor receptor signaling pathway | aging | carbohydrate homeostasis | glycoprotein metabolic process | muscle hypertrophy | positive regulation of nucleocytoplasmic transport | tissue regeneration | positive regulation of leukocyte cell-cell adhesion | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | negative regulation of cell differentiation | regulation of cellular component organization | muscle system process | response to other organism | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | response to glucocorticoid | regulation of glycogen metabolic process | proteoglycan biosynthetic process | regulation of hormone biosynthetic process | positive regulation of transcription regulatory region DNA binding | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | exocytic vesicle | extracellular matrix | insulin-like growth factor binding protein complex | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | plasma membrane protein complex | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | insulin-like growth factor ternary complex | platelet alpha granule | protein-containing complex | secretory vesicle | endomembrane system | plasma membrane | vesicle | transport vesicle | alphav-beta3 integrin-IGF-1-IGF1R complex | interstitial matrix | extracellular region | membrane-bounded organelle | organelle | extracellular space | cell periphery | intracellular vesicle | intracellular | membrane

PATHWAYS

SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | PID_ER_NONGENOMIC_PATHWAY | PID_SHP2_PATHWAY | PID_IGF1_PATHWAY | PID_CERAMIDE_PATHWAY | PID_AVB3_INTEGRIN_PATHWAY | PID_ECADHERIN_STABILIZATION_PATHWAY | NABA_SECRETED_FACTORS | NABA_MATRISOME_ASSOCIATED | NABA_MATRISOME

PROTEIN FAMILY

Insulin-like | Insulin-like growth factor I | Insulin-like growth factor | Insulin family | Insulin, conserved site | Insulin-like superfamily