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QuickView for IL-12B;jsessionid=417DB5A7B749F8DFC34C4940FE11F74B;jsessionid=4F7CF9C9FBA78E56CDFEBBAAD7BA0E6C (gene)


Gene Symbol:
Il12b Mus musculus Mus musculus
Full name:
interleukin 12b
Synonyms:
Il-12b, Il-12p40, Il12p40, p40, interleukin-12 subunit beta, CLMF p40, IL-12 p40 subunit, IL-12 subunit p40, IL-23 subunit p40, cytotoxic lymphocyte maturation factor 40 kDa subunit, interleukin-12 p40 subunit
Genomic Location:
Chr 11: 44213565-44227519
Description:
This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23.
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_008352
NM_001303244
Protein Names
Q9QUM1
Q3ZAX5
P43432



GO Molecular Function

cytokine binding | transmembrane signaling receptor activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | interleukin-12 binding | interleukin-12 alpha subunit binding | signaling receptor activity | identical protein binding | protein heterodimerization activity | cytokine receptor activity | protein binding | protein homodimerization activity | receptor regulator activity | protein dimerization activity | growth factor activity | receptor ligand activity | cytokine activity | interleukin-23 receptor binding

GO Biological Process

positive regulation of immune response | positive regulation of cell killing | regulation of T cell mediated immunity | adaptive immune response | response to radiation | response to virus | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | response to cytokine | cell motility | CD4-positive, alpha-beta T cell activation | response to lipopolysaccharide | positive regulation of apoptotic process | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell mediated cytotoxicity | negative regulation of growth of symbiont involved in interaction with host | defense response | regulation of leukocyte mediated cytotoxicity | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | defense response to Gram-negative bacterium | cellular process | negative regulation of inflammatory response | lymphocyte differentiation | localization | positive regulation of immune effector process | positive regulation of adaptive immune response | T-helper 1 type immune response | immune system development | positive regulation of protein kinase activity | positive regulation of defense response to virus by host | regulation of defense response to virus | regulation of cell cycle | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | positive regulation of natural killer cell proliferation | positive regulation of muscle cell apoptotic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of activated T cell proliferation | T cell differentiation involved in immune response | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | regulation of natural killer cell activation | T cell cytokine production | T cell activation | cellular response to interferon-gamma | positive regulation of natural killer cell mediated immunity | positive regulation of tumor necrosis factor production | positive regulation of interleukin-17 production | response to UV | response to stimulus | positive regulation of innate immune response | alpha-beta T cell activation involved in immune response | positive regulation of osteoclast differentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of smooth muscle cell apoptotic process | response to stress | positive regulation of JAK-STAT cascade | leukocyte activation involved in immune response | positive regulation of lymphocyte proliferation | regulation of activation of Janus kinase activity | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of natural killer cell activation | response to molecule of bacterial origin | positive regulation of T cell activation | hemopoiesis | regulation of cell adhesion | molecular function regulator | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | T-helper cell differentiation | leukocyte differentiation | locomotion | response to light stimulus | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | regulation of signal transduction | negative regulation of growth | multicellular organism development | cell migration | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | regulation of T cell activation | regulation of activated T cell proliferation | response to lipid | nervous system process | cell cycle | response to UV-B | negative regulation of cytokine production | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | negative regulation of smooth muscle cell proliferation | CD4-positive, alpha-beta T cell cytokine production | regulation of nitrogen compound metabolic process | positive regulation of STAT cascade | positive regulation of interleukin-12 production | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | alpha-beta T cell differentiation | negative regulation of interleukin-17 production | regulation of smooth muscle cell apoptotic process | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | cellular response to cytokine stimulus | cell proliferation | positive regulation of NK T cell activation | sensory perception of pain | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | negative regulation of immune response | T cell activation involved in immune response | cytokine production involved in immune response | regulation of tumor necrosis factor production | defense response to protozoan | cytokine receptor activity | response to bacterium | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of natural killer cell proliferation | positive regulation of NK T cell proliferation | positive regulation of tyrosine phosphorylation of STAT protein | T cell mediated immunity | cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | positive regulation of cell proliferation | regulation of protein phosphorylation | lymphocyte activation | positive regulation of molecular function | cytokine production | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | cell cycle arrest | regulation of JAK-STAT cascade | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | negative regulation of growth of symbiont in host | regulation of adaptive immune response | positive regulation of leukocyte activation | positive regulation of cell death | receptor ligand activity | immune response | cytokine activity | positive regulation of T-helper 1 type immune response | positive regulation of T cell mediated cytotoxicity | animal organ development | regulation of cell activation | positive regulation of programmed cell death | response to protozoan | positive regulation of kinase activity | alpha-beta T cell activation | regulation of phosphate metabolic process | positive regulation of natural killer cell mediated cytotoxicity | response to interferon-gamma | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | regulation of natural killer cell mediated cytotoxicity | negative regulation of cell cycle | sensory perception | regulation of osteoclast differentiation | regulation of cell communication | positive regulation of interleukin-10 production | natural killer cell activation | signaling | regulation of T cell proliferation | positive regulation of phosphorylation | regulation of cytokine production | response to biotic stimulus | natural killer cell activation involved in immune response | regulation of developmental process | developmental process | positive regulation of alpha-beta T cell activation | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of leukocyte mediated cytotoxicity | innate immune response | regulation of defense response to virus by host | T-helper 1 cell cytokine production | positive regulation of metabolic process | regulation of interferon-gamma production | positive regulation of myeloid leukocyte differentiation | immune system process | regulation of natural killer cell mediated immunity | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of inflammatory response to antigenic stimulus | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | positive regulation of immune response to tumor cell | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of activation of Janus kinase activity | interferon-gamma production | cellular response to lipopolysaccharide | multicellular organismal process | negative regulation of interleukin-10 production | regulation of phosphorus metabolic process

GO Cellular Component

cell | interleukin-12 complex | cytoplasm | interleukin-23 complex | protein-containing complex | extracellular region | extracellular space | cell surface | intracellular | membrane