QuickView for IL2RA;jsessionid=5CBC98CF216FAC8781D8A238A8FA2500;jsessionid=DD7E8A4D8DA2A213C697871474C2F568;jsessionid=458CBF64BEAD4674120396B3417C7FFF (gene)
- Gene Symbol:
- IL2RA
Homo sapiens - Full name:
- interleukin 2 receptor subunit alpha
- Synonyms:
- CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha
- Genomic Location:
- Chr 10: 6093512-6144278
- Description:
-
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
GNCF_01 , FOXJ2_02 , PEA3_Q6 , NFKAPPAB_01 , AR_Q6 , MGGAAGTG_GABP_B , TGCCAAR_NF1_Q6 , NF1_Q6_01 , RNGTGGGC_UNKNOWN , CREL_01
- Cytogenetic Map:
-
10p15.1
GO Molecular Function
cytokine binding | guanyl-nucleotide exchange factor activity | GTPase binding | transmembrane signaling receptor activity | enzyme binding | interleukin-2 binding | Ras GTPase binding | growth factor binding | molecular function regulator | signaling receptor activity | cytokine receptor activity | protein binding | interleukin-2 receptor activity | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | drug binding
GO Biological Process
leukocyte homeostasis | negative regulation of leukocyte activation | Notch signaling pathway | interleukin-2-mediated signaling pathway | negative regulation of immune system process | guanyl-nucleotide exchange factor activity | response to cytokine | intracellular signal transduction | cellular response to interleukin-2 | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of T cell differentiation | defense response | positive regulation of cell adhesion | positive regulation of T cell differentiation | cellular process | negative regulation of inflammatory response | regulation of defense response to virus | negative regulation of T cell proliferation | regulation of cell differentiation | regulation of immune response | regulation of cellular process | positive regulation of activated T cell proliferation | negative regulation of mononuclear cell proliferation | MAPK cascade | response to stimulus | regulation of regulatory T cell differentiation | positive regulation of immune system process | signal transduction by protein phosphorylation | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | inflammatory response to antigenic stimulus | programmed cell death | positive regulation of cell activation | positive regulation of T cell activation | protein modification process | regulation of cell adhesion | macromolecule modification | molecular function regulator | regulation of lymphocyte differentiation | apoptotic process | positive regulation of mononuclear cell proliferation | negative regulation of defense response to virus | nitrogen compound metabolic process | positive regulation of lymphocyte differentiation | phosphorus metabolic process | response to interleukin-2 | regulation of T cell activation | regulation of activated T cell proliferation | regulation of lymphocyte activation | regulation of tolerance induction | regulation of T cell homeostatic proliferation | negative regulation of T cell activation | cytokine-mediated signaling pathway | positive regulation of cell differentiation | homeostasis of number of cells | T cell apoptotic process | cellular response to cytokine stimulus | cell proliferation | positive regulation of T cell proliferation | negative regulation of immune response | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cytokine receptor activity | negative regulation of cell-cell adhesion | cell communication | lymphocyte homeostasis | negative regulation of cell activation | inflammatory response | homeostatic process | positive regulation of cell proliferation | activation-induced cell death of T cells | interleukin-2 receptor activity | protein metabolic process | response to organic substance | regulation of hemopoiesis | cell surface receptor signaling pathway | metabolic process | negative regulation of leukocyte proliferation | positive regulation of leukocyte activation | regulation of T cell tolerance induction | Ras guanyl-nucleotide exchange factor activity | immune response | organic substance metabolic process | cell death | regulation of cell activation | T cell homeostasis | signaling | regulation of T cell proliferation | cellular protein metabolic process | regulation of developmental process | cellular protein modification process | negative regulation of cell proliferation | regulation of cell-cell adhesion | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | cellular response to organic substance | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | signal transduction | macromolecule metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | plasma membrane | cell periphery | cell surface | intracellular | membrane
