QuickView for Irs1;jsessionid=27E02E8598E8966DEED9987D37591BC3;jsessionid=CE3CD5412B0C1EDB4D0C6A70939009C7;jsessionid=D0F27441242D27D237BF97487A2EBBA3 (gene)
- Gene Symbol:
- Irs1
Rattus norvegicus - Full name:
- insulin receptor substrate 1
- Synonyms:
- IRS1IRM, insulin receptor substrate 1, IRS-1, pp185
- Genomic Location:
- Chr 9: 81585251-81638071
- Description:
-
a docking protein; may act to link the insulin receptor kinase with enzymes regulating cellular growth and metabolism
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
RSRFC4_01 , MEF2_02 , MEF2_03 , RSRFC4_Q2 , TGIF_01 , MEIS1BHOXA9_01 , CTGCAGY_UNKNOWN , NKX62_Q2 , SP3_Q3 , ALPHACP1_01
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-126 , Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-487b , Predicted Gene Targets for miR-96
GO Molecular Function
protein phosphorylated amino acid binding | phosphatidylinositol 3-kinase binding | kinase binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | protein-containing complex binding | phosphotyrosine residue binding | transmembrane receptor protein tyrosine kinase adaptor activity | signaling receptor binding | signaling adaptor activity | protein domain specific binding | protein kinase C binding | protein binding, bridging | protein tyrosine kinase binding | molecular adaptor activity | phosphoprotein binding | protein binding | insulin receptor binding | insulin-like growth factor receptor binding | SH2 domain binding
GO Biological Process
positive regulation of glycogen biosynthetic process | response to radiation | negative regulation of cellular response to insulin stimulus | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | negative regulation of peptide secretion | intracellular signal transduction | regulation of localization | regulation of carbohydrate metabolic process | hormone secretion | positive regulation of lipid catabolic process | establishment of localization | response to hormone | negative regulation of cellular process | positive regulation of fatty acid oxidation | response to drug | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of cellular component movement | regulation of peptide hormone secretion | positive regulation of phosphatidylinositol 3-kinase activity | positive regulation of cellular biosynthetic process | cellular process | secretion | peptide hormone secretion | organic substance catabolic process | regulation of glucose import | regulation of cell motility | localization | protein transport | negative regulation of signaling | macromolecule localization | negative regulation of secretion | response to growth factor | positive regulation of catalytic activity | negative regulation of hormone secretion | negative regulation of establishment of protein localization | response to peptide hormone | regulation of cellular process | positive regulation of insulin receptor signaling pathway | regulation of metabolic process | catabolic process | response to nerve growth factor | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | cellular component organization | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | transmembrane receptor protein tyrosine kinase adaptor activity | regulation of insulin secretion | regulation of cell proliferation | regulation of somatostatin secretion | response to peptide | protein localization to nucleus | positive regulation of glucose import | phosphatidylinositol-mediated signaling | cellular localization | secretion by cell | positive regulation of hormone secretion | negative regulation of transport | regulation of protein transport | cellular component assembly | regulation of peptide transport | regulation of phosphatidylinositol 3-kinase activity | cell-cell signaling | insulin secretion | positive regulation of peptide secretion | response to nitrogen compound | protein kinase B signaling | cellular response to hormone stimulus | signaling adaptor activity | system development | regulation of signal transduction | negative regulation of secretion by cell | regulation of fatty acid beta-oxidation | multicellular organism development | response to activity | cellular response to peptide hormone stimulus | response to purine-containing compound | mammary gland development | protein complex oligomerization | cellular response to insulin stimulus | regulation of catalytic activity | lipid metabolic process | cellular response to nerve growth factor stimulus | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | positive regulation of glucose import in response to insulin stimulus | regulation of gene expression | positive regulation of secretion | organic substance transport | cellular response to peptide | regulation of glucose import in response to insulin stimulus | insulin receptor signaling pathway | positive regulation of cellular metabolic process | cellular response to radiation | positive regulation of glucagon secretion | regulation of cell migration | enzyme linked receptor protein signaling pathway | negative regulation of insulin receptor signaling pathway | peptide transport | regulation of cellular component movement | protein localization to organelle | regulation of fatty acid metabolic process | positive regulation of cell migration | positive regulation of glucose transmembrane transport | negative regulation of peptide hormone secretion | inositol lipid-mediated signaling | response to xenobiotic stimulus | positive regulation of cellular response to insulin stimulus | cellular response to angiotensin | regulation of lipid kinase activity | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of lipid catabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of locomotion | positive regulation of transport | regulation of phospholipid metabolic process | positive regulation of peptide hormone secretion | positive regulation of molecular function | response to angiotensin | protein-containing complex assembly | regulation of establishment of protein localization | response to organic substance | gland development | positive regulation of fatty acid beta-oxidation | regulation of kinase activity | positive regulation of fatty acid metabolic process | phosphatidylinositol 3-kinase signaling | response to insulin | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | positive regulation of glucose metabolic process | cellular protein localization | amide transport | regulation of secretion | hormone transport | lipid catabolic process | response to caffeine | organic substance metabolic process | regulation of glucose transmembrane transport | animal organ development | regulation of insulin receptor signaling pathway | regulation of protein secretion | cellular response to brain-derived neurotrophic factor stimulus | positive regulation of kinase activity | regulation of fatty acid oxidation | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | response to alkaloid | establishment of protein localization | positive regulation of carbohydrate metabolic process | regulation of cell communication | negative regulation of signal transduction | negative regulation of insulin secretion | signaling | response to organic cyclic compound | protein localization | positive regulation of phosphorylation | protein heterooligomerization | cellular macromolecule localization | regulation of glucagon secretion | regulation of cellular ketone metabolic process | regulation of mesenchymal cell proliferation | developmental process | regulation of transport | positive regulation of mesenchymal cell proliferation | signal release | positive regulation of lipid kinase activity | response to organonitrogen compound | regulation of glycogen biosynthetic process | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | negative regulation of somatostatin secretion | positive regulation of lipid metabolic process | cellular response to organic substance | regulation of protein localization | protein secretion | positive regulation of cell motility | aging | positive regulation of signaling | signal transduction | regulation of signaling | regulation of glycogen metabolic process | cellular response to growth factor stimulus | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | protein kinase complex | cell | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | protein-containing complex | cell projection | plasma membrane | cilium | membrane raft | transferase complex | microtubule cytoskeleton | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | insulin receptor complex | cell periphery | plasma membrane raft | cytosol | cytoskeleton | intracellular | caveola | membrane | ciliary basal body | intrinsic component of plasma membrane
