QuickView for JAK3;jsessionid=CA5C011F865AD03678A43C7176E21844 (gene)
- Gene Symbol:
- Jak3
Rattus norvegicus - Full name:
- Janus kinase 3
- Synonyms:
- RATJAK3, tyrosine-protein kinase JAK3, JAK-3, Janus kinase 3, protein-tyrosine kinase
- Genomic Location:
- Chr 16: 18878139-18889441
- Description:
-
tyrosine kinase; member of the JAK family of protein kinases
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
NFKAPPAB65_01 , CREL_01 , NFKAPPAB_01 , NFKB_Q6 , NFKB_C , STAT1_01 , MSX1_01 , NFKB_Q6_01 , RYTTCCTG_ETS2_B , GGGNNTTTCC_NFKB_Q6_01
GO Molecular Function
enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | negative regulation of lymphocyte differentiation | leukocyte homeostasis | negative regulation of leukocyte activation | adaptive immune response | regulation of extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | response to cytokine | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | erythrocyte homeostasis | regulation of immune system process | myeloid cell differentiation | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | JAK-STAT cascade | cellular chemical homeostasis | positive regulation of cell adhesion | peptidyl-tyrosine phosphorylation | B cell differentiation | negative regulation of T-helper 1 cell differentiation | positive regulation of dendritic cell apoptotic process | positive regulation of cellular biosynthetic process | cellular process | lymphocyte differentiation | cellular homeostasis | immune system development | negative regulation of alpha-beta T cell differentiation | negative regulation of apoptotic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | regulation of lymphocyte apoptotic process | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of activated T cell proliferation | regulation of cytosolic calcium ion concentration | calcium ion homeostasis | response to stimulus | regulation of glycoprotein biosynthetic process | negative regulation of T cell apoptotic process | positive regulation of immune system process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | protein modification process | regulation of cell adhesion | macromolecule modification | metal ion homeostasis | regulation of lymphocyte differentiation | negative regulation of adaptive immune response | myeloid cell homeostasis | regulation of nucleic acid-templated transcription | leukocyte differentiation | positive regulation of mononuclear cell proliferation | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of T-helper cell differentiation | multicellular organism development | phosphorus metabolic process | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | regulation of activated T cell proliferation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | negative regulation of cytokine production | positive regulation of cellular metabolic process | regulation of lymphocyte activation | cellular ion homeostasis | negative regulation of lymphocyte apoptotic process | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | negative regulation of FasL biosynthetic process | regulation of transcription by RNA polymerase II | homeostasis of number of cells | cellular response to cytokine stimulus | B cell activation | negative regulation of interleukin-12 production | negative regulation of T-helper 1 type immune response | positive regulation of T cell proliferation | negative regulation of immune response | phosphorylation | positive regulation of leukocyte apoptotic process | regulation of apoptotic signaling pathway | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | lymphocyte homeostasis | negative regulation of cell activation | regulation of T cell apoptotic process | regulation of cytokine production involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of RNA metabolic process | positive regulation of transport | negative regulation of T cell differentiation | lymphocyte activation | protein tyrosine kinase activity | negative regulation of thymocyte apoptotic process | cellular response to interleukin-4 | protein metabolic process | response to organic substance | regulation of hemopoiesis | anatomical structure development | cell surface receptor signaling pathway | interleukin-4-mediated signaling pathway | metabolic process | regulation of adaptive immune response | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | chemical homeostasis | positive regulation of cell death | negative regulation of glycoprotein metabolic process | immune response | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | positive regulation of ion transport | regulation of cell activation | positive regulation of programmed cell death | ion homeostasis | regulation of dendritic cell cytokine production | T cell homeostasis | cell activation | regulation of T-helper cell differentiation | negative regulation of protein metabolic process | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | regulation of T-helper 1 cell differentiation | signaling | regulation of transcription, DNA-templated | regulation of T cell proliferation | negative regulation of leukocyte apoptotic process | cellular protein metabolic process | regulation of cytokine production | tyrosine phosphorylation of STAT protein | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | erythrocyte differentiation | regulation of calcium ion transport | cellular protein modification process | negative regulation of alpha-beta T cell activation | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | negative regulation of dendritic cell cytokine production | positive regulation of nucleic acid-templated transcription | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of cell death | divalent inorganic cation homeostasis | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | positive regulation of calcium ion transport | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | negative regulation of interleukin-10 production | response to interleukin-4
GO Cellular Component
cell | cytoplasm | intracellular organelle | endomembrane system | organelle | cytoskeleton | intracellular | membrane
