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QuickView for KALRN;jsessionid=851C9E7D347AA3D49E84C243D61FDCA6;jsessionid=72DDE11E1440E83CB8259FBDA6F37BDF;jsessionid=2A4CDFEDDE5195D62C4A5BB2A534FEA1 (gene)


Gene Symbol:
Kalrn Rattus norvegicus Rattus norvegicus
Full name:
kalirin, RhoGEF kinase
Synonyms:
Duo, Hapip, Kalirin, kalirin, P-CIP10, PAM COOH-terminal interactor protein 10, cyclin B1, huntingtin-associated protein interacting protein (duo), huntingtin-associated protein-interacting protein, protein Duo, serine/threonine kinase with Dbl- and pleckstrin homology domain, serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Genomic Location:
Chr 11: 68124348-68611336
Description:
binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins
Orthologs:
Homo sapiens Mus musculus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_032062



GO Molecular Function

Rho guanyl-nucleotide exchange factor activity | guanyl-nucleotide exchange factor activity | GTPase binding | Rho GTPase binding | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | Rac GTPase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | Rac guanyl-nucleotide exchange factor activity | heterocyclic compound binding | small molecule binding

GO Biological Process

behavioral response to pain | cell morphogenesis | Rho guanyl-nucleotide exchange factor activity | chemosensory behavior | guanyl-nucleotide exchange factor activity | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | behavioral fear response | protein localization to cell periphery | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | social behavior | regulation of protein localization to membrane | cell differentiation | defense response | nervous system development | response to drug | cell part morphogenesis | NMDA selective glutamate receptor signaling pathway | neurogenesis | regulation of peptide hormone secretion | generation of neurons | positive regulation of dendritic spine morphogenesis | behavioral response to formalin induced pain | positive regulation of GTPase activity | cellular process | secretion | regulation of dendritic spine morphogenesis | localization | cell projection morphogenesis | positive regulation of synaptic transmission | regulation of growth hormone secretion | negative regulation of signaling | neuron development | regulation of neuronal synaptic plasticity | habituation | multicellular organismal reproductive process | learning | macromolecule localization | negative regulation of secretion | protein localization to postsynaptic membrane | positive regulation of catalytic activity | regulation of neuron projection development | negative regulation of hormone secretion | regulation of cell differentiation | regulation of cellular process | parturition | small GTPase mediated signal transduction | cellular component organization | positive regulation of dendrite morphogenesis | regulation of peptide secretion | modification of synaptic structure | response to stimulus | maternal behavior | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | regulation of long-term synaptic potentiation | response to pain | response to cocaine | response to stress | negative regulation of growth hormone secretion | positive regulation of long-term synaptic potentiation | protein serine/threonine kinase activity | reproduction | cellular localization | negative regulation of transport | protein modification process | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | macromolecule modification | molecular function regulator | locomotion | response to nitrogen compound | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of neuron projection development | multicellular organism development | cell migration | regulation of synaptic transmission, glutamatergic | phosphorus metabolic process | learning or memory | mammary gland development | regulation of catalytic activity | regulation of hormone levels | regulation of hormone secretion | localization within membrane | nonassociative learning | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | protein localization to membrane | axon development | nervous system process | neuromuscular junction development | adult locomotory behavior | response to ammonium ion | regulation of synapse organization | positive regulation of cell projection organization | synapse organization | axonogenesis | protein localization to organelle | positive regulation of hydrolase activity | behavioral response to cocaine | positive regulation of cell differentiation | cognition | regulation of Rho protein signal transduction | cell proliferation | neurotransmitter receptor localization to postsynaptic specialization membrane | locomotory behavior | negative regulation of peptide hormone secretion | phosphorylation | parental behavior | regulation of GTPase activity | positive regulation of dendritic spine development | response to xenobiotic stimulus | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | receptor localization to synapse | protein localization to synapse | cell communication | smooth muscle cell migration | protein-containing complex localization | positive regulation of dendrite development | positive regulation of molecular function | neuron differentiation | multicellular organism reproduction | maternal process involved in parturition | multicellular organismal response to stress | regulation of cell morphogenesis involved in differentiation | fear response | protein metabolic process | muscle cell migration | response to organic substance | gland development | Rho protein signal transduction | lactation | response to mechanical stimulus | regulation of intracellular signal transduction | anatomical structure development | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | reproductive behavior | cell projection organization | metabolic process | positive regulation of cell development | regulation of protein localization to plasma membrane | regulation of body fluid levels | smooth muscle cell proliferation | cellular protein localization | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | behavior | body fluid secretion | protein kinase activity | neuron projection development | organic substance metabolic process | animal organ development | response to alkaloid | regulation of postsynapse organization | memory | adult behavior | regulation of dendrite development | regulation of cell communication | muscle cell proliferation | regulation of dendritic spine development | signaling | response to organic cyclic compound | cell development | protein localization | cellular protein metabolic process | regulation of Ras protein signal transduction | anatomical structure morphogenesis | cellular macromolecule localization | glutamate receptor signaling pathway | modification of postsynaptic actin cytoskeleton | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | behavioral defense response | cellular protein modification process | regulation of transport | Ras protein signal transduction | response to organonitrogen compound | response to anesthetic | regulation of synaptic plasticity | positive regulation of neuron differentiation | Rac guanyl-nucleotide exchange factor activity | regulation of cell projection organization | cellular metabolic process | regulation of protein localization | positive regulation of cell morphogenesis involved in differentiation | ionotropic glutamate receptor signaling pathway | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | nuclear lumen | neuronal cell body | cytoplasm | intracellular organelle | cell projection | postsynapse | nucleoplasm | perinuclear region of cytoplasm | postsynaptic density | asymmetric synapse | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane