QuickView for Kap104p;jsessionid=80AC6139235C952752253288DF341B0F;jsessionid=6E5BBD524F063D52C558B0D73A86C6C6;jsessionid=260D2AE61BB405DF2A9433B4C9629744 (gene)
- Gene Symbol:
- TNPO1
Homo sapiens - Full name:
- transportin 1
- Synonyms:
- IPO2, KPNB2, MIP, MIP1, TRN, transportin-1, M9 region interaction protein, importin 2, importin beta 2, karyopherin (importin) beta 2, karyopherin beta-2
- Genomic Location:
- Chr 5: 72148174-72245971
- Description:
-
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alterna...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q13.2
GO Molecular Function
nuclear localization sequence binding | GTPase binding | peptide binding | enzyme binding | nucleic acid binding | protein transporter activity | signal sequence binding | Ras GTPase binding | amide binding | transporter activity | organic cyclic compound binding | protein binding | Ran GTPase binding | small GTPase binding | heterocyclic compound binding | RNA binding
GO Biological Process
microtubule-based transport | ribosomal protein import into nucleus | NLS-bearing protein import into nucleus | establishment of localization | intracellular transport | microtubule-based process | cellular process | localization | protein transport | macromolecule localization | establishment of localization in cell | interspecies interaction between organisms | cytoskeleton-dependent intracellular transport | regulation of mRNA stability | regulation of cellular process | regulation of metabolic process | protein import into nucleus | cellular component organization | protein transporter activity | intracellular protein transport | posttranscriptional regulation of gene expression | protein localization to nucleus | microtubule-based movement | cellular localization | cellular component assembly | organelle assembly | protein import into nucleus, translocation | regulation of gene expression | organic substance transport | cell projection assembly | regulation of nitrogen compound metabolic process | peptide transport | regulation of RNA stability | protein localization to organelle | import into nucleus | protein import | regulation of cellular metabolic process | intraciliary transport | protein-containing complex localization | regulation of RNA metabolic process | viral process | intraciliary transport involved in cilium assembly | establishment of protein localization to organelle | cell projection organization | transport along microtubule | cellular protein localization | amide transport | nuclear transport | regulation of mRNA catabolic process | cilium assembly | establishment of protein localization | cilium organization | protein localization | cellular macromolecule localization | nucleocytoplasmic transport | organelle organization
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | cytoplasm | intracellular organelle | cell projection | endomembrane system | nuclear envelope | cilium | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular | membrane | nuclear periphery
