QuickView for L-myc;jsessionid=A0A3925D9DE9DEA3695E2DB1673C7235;jsessionid=641F7D353C1D6AB573887AF87DA64D1E (gene)

Gene Symbol:

Mycl Mus musculus

Full name:

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived

Synonyms:

AW536278, L-myc, Lmyc-1, Lmyc1, Mycl1, bHLHe38, protein L-Myc, L-myc-1 proto-oncogene protein, lung carcinoma myc related oncogene 1, protein L-Myc-1, v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived, v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived

Genomic Location:

Chr 4: 122673342-122679728

Description:

This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene ...

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This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAANWWTGC_UNKNOWN ,  AACTTT_UNKNOWN ,  P300_01 ,  NMYC_01 ,  MYOGNF1_01 ,  MYCMAX_01 ,  MYOD_Q6 ,  NF1_Q6 ,  USF_C ,  OLF1_01 ,  LMO2COM_01 ,  ZF5_B ,  AP2GAMMA_01 ,  CTCNANGTGNY_UNKNOWN ,  CTTTAAR_UNKNOWN ,  DBP_Q6 ,  TCF4_Q5 ,  SMAD3_Q6 ,  CACCCBINDINGFACTOR_Q6 ,  USF2_Q6 ,  LEF1_Q6 ,  MYC_Q2 ,  E2F_Q2 ,  LEF1_Q2 ,  NF1_Q6_01 ,  MYOD_Q6_01 ,  GGGYGTGNY_UNKNOWN ,  TTTGCAC_MIR19A_MIR19B ,  GTGGGTGK_UNKNOWN ,  GCGCCTT_MIR525_MIR524 ,  CTATGCA_MIR153 ,  AAAGGAT_MIR501 ,  GGCAGCT_MIR22 ,  GAGCCAG_MIR149 ,  RAAGNYNNCTTY_UNKNOWN ,  CCAGGGG_MIR331 ,  GGTGTGT_MIR329 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  CTTTGA_LEF1_Q2 ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-149

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