QuickView for LEPR;jsessionid=C1BD63441D4EE3380F48182DE6CCDEA4;jsessionid=B62E88DB27B5C87A8A2ED50AD64C369F;jsessionid=BE3FA1FA7109A57A1F110EF45672D4E4 (gene)
- Gene Symbol:
- Lepr
Rattus norvegicus - Full name:
- leptin receptor
- Synonyms:
- Fa, leptin receptor, LEP-R, Leptin receptor (fatty), OB receptor, OB-R
- Genomic Location:
- Chr 5: 122320075-122503451
- Description:
-
receptor for leptin; may have a role in body weight maintainence
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
cytokine binding | peptide binding | peptide hormone binding | transmembrane signaling receptor activity | leptin receptor activity | amide binding | signaling receptor activity | identical protein binding | cytokine receptor activity | hormone binding | protein binding | protein-hormone receptor activity
GO Biological Process
response to extracellular stimulus | positive regulation of insulin secretion involved in cellular response to glucose stimulus | response to nutrient levels | response to cytokine | developmental process involved in reproduction | regulation of cellular localization | regulation of localization | gonad development | regulation of carbohydrate metabolic process | female gonad development | establishment of localization | regulation of autophagy | response to hormone | negative regulation of cellular process | response to dexamethasone | cell differentiation | response to drug | organ growth | generation of precursor metabolites and energy | glucose homeostasis | positive regulation of phosphate metabolic process | regulation of peptide hormone secretion | positive regulation of protein secretion | blood vessel morphogenesis | regulation of bone remodeling | sterol metabolic process | cellular process | lymphocyte differentiation | localization | developmental growth | negative regulation of gluconeogenesis | reproductive system development | female pregnancy | immune system development | multicellular organismal reproductive process | response to hypoxia | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of behavior | gamete generation | regulation of cellular process | leukocyte activation | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | T cell activation | development of primary sexual characteristics | regulation of peptide secretion | response to stimulus | ovulation | vasculature development | female gamete generation | regulation of feeding behavior | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | negative regulation of circadian rhythm | alcohol metabolic process | ovulation cycle | multicellular organismal homeostasis | tube morphogenesis | negative regulation of eating behavior | development of primary female sexual characteristics | reproduction | cardiovascular system development | rhythmic process | positive regulation of hormone secretion | regulation of protein transport | negative regulation of metabolic process | hemopoiesis | regulation of peptide transport | ovulation from ovarian follicle | blood vessel development | positive regulation of peptide secretion | leukocyte differentiation | organic hydroxy compound metabolic process | leptin receptor activity | cellular response to hormone stimulus | response to nicotine | system development | response to oxygen levels | reproductive process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | lipid metabolic process | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | positive regulation of secretion | response to ketone | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | small molecule metabolic process | cytokine-mediated signaling pathway | bone growth | positive regulation of intracellular signal transduction | response to corticosteroid | vesicle-mediated transport | response to nutrient | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | eating behavior | angiogenesis | response to toxic substance | leptin-mediated signaling pathway | response to xenobiotic stimulus | negative regulation of autophagy | ovulation cycle process | cytokine receptor activity | energy homeostasis | response to estrogen | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of transport | positive regulation of peptide hormone secretion | lymphocyte activation | multicellular organism reproduction | T cell differentiation | development of primary male sexual characteristics | negative regulation of carbohydrate metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | negative regulation of behavior | regulation of eating behavior | positive regulation of insulin secretion | male sex differentiation | response to wounding | response to antineoplastic agent | import into cell | regulation of intracellular signal transduction | response to leptin | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | negative regulation of feeding behavior | cholesterol metabolic process | male gonad development | regulation of tissue remodeling | chemical homeostasis | endocytosis | regulation of secretion | behavior | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | regulation of protein secretion | regulation of phosphate metabolic process | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | steroid metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of locomotor rhythm | signaling | feeding behavior | response to organic cyclic compound | positive regulation of phosphorylation | anatomical structure morphogenesis | regulation of circadian rhythm | reproductive structure development | developmental process | tube development | regulation of transport | negative regulation of hydrolase activity | regulation of gluconeogenesis | positive regulation of metabolic process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | regulation of locomotor rhythm | female sex differentiation | cellular response to organic substance | regulation of protein localization | sex differentiation | response to steroid hormone | circulatory system development | aging | carbohydrate homeostasis | sexual reproduction | phagocytosis | positive regulation of signaling | signal transduction | cellular response to leptin stimulus | regulation of signaling | response to glucocorticoid | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | external side of plasma membrane | receptor complex | protein-containing complex | plasma membrane | extracellular region | extracellular space | cell periphery | basolateral plasma membrane | cell surface | membrane
