QuickView for LOX;jsessionid=F72C99E8335D812E716B4F224D4ED806;jsessionid=6F196F38DFE36560E7517FEB8B4A0608;jsessionid=D515E9DF0B0A947CD4F44E725DA6D64D (gene)

Gene Symbol:

Lox Mus musculus

Full name:

lysyl oxidase

Synonyms:

AI893619, TSC-160, rrg, protein-lysine 6-oxidase, ras excision protein, ras recision

Genomic Location:

Chr 18: 52675721-52689357

Description:

This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collage...

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This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAANWWTGC_UNKNOWN ,  AACTTT_UNKNOWN ,  IRF1_01 ,  EVI1_04 ,  OCT1_02 ,  OCT1_06 ,  ER_Q6 ,  GR_Q6 ,  TATA_C ,  HLF_01 ,  FREAC4_01 ,  IPF1_Q4 ,  IRF7_01 ,  POU3F2_01 ,  POU3F2_02 ,  FOXO4_02 ,  PAX2_02 ,  TEF_Q6 ,  SMAD3_Q6 ,  CDX2_Q5 ,  IRF1_Q6 ,  GCTNWTTGK_UNKNOWN ,  NF1_Q6_01 ,  GR_Q6_01 ,  AR_02 ,  GR_01 ,  PR_02 ,  PR_Q2 ,  AACTGGA_MIR145 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TTANTCA_UNKNOWN ,  WTGAAAT_UNKNOWN ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  YTATTTTNR_MEF2_02 ,  TGGAAA_NFAT_Q4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145

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