QuickView for Liprin;jsessionid=B2D03B5D79EEB016E72CDB58C58C07DA;jsessionid=8246B1468A3AA0E0D00217F31ACBEBC7 (gene)

Gene Symbol:

PPFIA1 Homo sapiens

Full name:

PTPRF interacting protein alpha 1

Synonyms:

LIP.1, LIP1, LIPRIN, liprin-alpha-1, LAR-interacting protein 1, LIP-1, Liprin-alpha1, protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

Genomic Location:

Chr 11: 69794471-69908150

Description:

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal...

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The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CACTGCC_MIR34A_MIR34C_MIR449 ,  E4BP4_01 ,  GTACTGT_MIR101 ,  TTAYRTAA_E4BP4_01 ,  TEF1_Q6 ,  AP2_Q6 ,  WGGAATGY_TEF1_Q6 ,  ACACTAC_MIR1423P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-181

Cytogenetic Map:

11q13.3

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