QuickView for MAG;jsessionid=790E4D8FD9932C7AA960D21CA94A3A22;jsessionid=D0DA9F0D1548D57565BE83D0638CB5CF (gene)

Gene Symbol:

Mag Mus musculus

Full name:

myelin-associated glycoprotein

Synonyms:

Gma, siglec-4a, myelin-associated glycoprotein

Genomic Location:

Chr 7: 31684202-31699851

Description:

This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, alte...

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This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFKAPPAB_01 ,  HEN1_01 ,  IK3_01 ,  CDPCR1_01 ,  CDPCR3HD_01 ,  NFKB_Q6 ,  NFKB_C ,  CATRRAGC_UNKNOWN ,  OLF1_01 ,  STAT1_03 ,  NFKB_Q6_01 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TCCCRNNRTGC_UNKNOWN ,  TGACATY_UNKNOWN ,  TGCTGAY_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  CTTTGT_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  CCCNNGGGAR_OLF1_01 ,  GGGTGGRR_PAX4_03

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