QuickView for MAP3K12;jsessionid=EC691E8812CD6D3F2F19CAD0EF2278E3;jsessionid=D0F3BD088158B1176E95F6DAC5570CFD (gene)
- Gene Symbol:
- Map3k12
Rattus norvegicus - Full name:
- mitogen activated protein kinase kinase kinase 12
- Synonyms:
- DLK, MUK, PK, Zpk, mitogen-activated protein kinase kinase kinase 12, MAPK-upstream kinase, Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase), Zipper (leucine) protein kinase, dual leucine zipper bearing kinase, dual leucine zipper kinase, leucine-zipper protein kinase, mixed lineage kinase
- Genomic Location:
- Chr 7: 141254451-141264979
- Description:
-
kinase which is an activator of the JNK-pathway
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-122a , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-150 , Predicted Gene Targets for miR-19 , Predicted Gene Targets for miR-191 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-539
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | JUN kinase kinase kinase activity | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of JUN kinase activity | intracellular signal transduction | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of neuron death | negative regulation of cellular process | regulation of MAP kinase activity | histone modification | positive regulation of phosphate metabolic process | regulation of neuron death | cellular process | chromatin organization | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of cellular protein metabolic process | cellular component organization | MAPK cascade | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | peptidyl-threonine phosphorylation | JNK cascade | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | protein serine/threonine kinase activity | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of cellular response to stress | negative regulation of neuron apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of motor neuron apoptotic process | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | MAP kinase kinase kinase activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | JUN kinase kinase kinase activity | regulation of neuron apoptotic process | activation of MAPKK activity | activation of JNKK activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | histone phosphorylation | negative regulation of motor neuron apoptotic process | positive regulation of molecular function | activation of MAPK activity | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | negative regulation of programmed cell death | protein kinase activity | organic substance metabolic process | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of JNK cascade | positive regulation of MAPK cascade | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | covalent chromatin modification | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of MAP kinase activity | kinase activity | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of JUN kinase activity | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of cell death | activation of JUN kinase activity | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
neuron projection | cell | distal axon | cytoplasm | cell projection | plasma membrane | site of polarized growth | cell periphery | axon | growth cone | cytosol | intracellular | membrane
