QuickView for MAPK8;jsessionid=E3F124DE96375F03B13295AAA8586C4C (gene)
- Gene Symbol:
- Mapk8
Mus musculus - Full name:
- mitogen-activated protein kinase 8
- Synonyms:
- AI849689, JNK, JNK1, Prkm8, SAPK1, mitogen-activated protein kinase 8, JNK1 beta1 protein kinase, MAP kinase 8, MAPK 8, c-Jun N-terminal kinase 1, protein kinase mitogen-activated 8, stress-activated protein kinase JNK1
- Genomic Location:
- Chr 14: 34195195-34260343
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
histone deacetylase regulator activity | JUN kinase activity | enzyme binding | ribonucleotide binding | SAP kinase activity | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | kinesin binding | purine nucleotide binding | MAP kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | protein serine/threonine/tyrosine kinase activity | drug binding | kinase activity | histone deacetylase binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of cyclase activity | response to extracellular stimulus | regulation of supramolecular fiber organization | positive regulation of deacetylase activity | response to radiation | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | neuron projection morphogenesis | response to lipopolysaccharide | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | JUN phosphorylation | regulation of programmed cell death | peptidyl-amino acid modification | epithelial cell apoptotic process | neuron migration | negative regulation of cellular process | positive regulation of developmental process | response to metal ion | regulation of cardiac muscle cell apoptotic process | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | defense response | nervous system development | cellular response to extracellular stimulus | positive regulation of protein catabolic process | response to drug | positive regulation of glial cell apoptotic process | histone deacetylase regulator activity | cell part morphogenesis | neurogenesis | regulation of DNA replication | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | response to antibiotic | regulation of neuroblast proliferation | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | positive regulation of microtubule polymerization | regulation of neuron migration | regulation of cell motility | localization | JUN kinase activity | cell projection morphogenesis | cellular response to nitric oxide | neuron development | programmed necrotic cell death | stem cell population maintenance | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | cellular response to starvation | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of muscle cell apoptotic process | response to inorganic substance | regulation of binding | regulation of cell differentiation | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | cellular response to molecule of bacterial origin | SAP kinase activity | positive regulation of cellular protein metabolic process | positive regulation of transcription factor catabolic process | cellular component organization | MAPK cascade | cellular response to metal ion | response to UV | positive regulation of cellular protein catabolic process | response to stimulus | peptidyl-threonine phosphorylation | cell morphogenesis involved in neuron differentiation | JNK cascade | regulation of centrosome cycle | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | regulation of cellular protein catabolic process | response to stress | regulation of cell proliferation | regulation of protein ubiquitination | positive regulation of neuroblast proliferation | response to starvation | protein serine/threonine kinase activity | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | cellular response to inorganic substance | response to temperature stimulus | rhythmic process | cellular response to cadmium ion | positive regulation of proteolysis | response to molecule of bacterial origin | cellular response to toxic substance | regulation of DNA binding | protein modification process | dorsal/ventral pattern formation | macromolecule modification | molecular function regulator | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | type B pancreatic cell apoptotic process | locomotion | response to nitrogen compound | apoptotic process | response to light stimulus | response to external biotic stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | cellular response to antibiotic | multicellular organism development | cell migration | positive regulation of DNA replication | phosphorus metabolic process | positive regulation of organelle assembly | positive regulation of podosome assembly | regulation of catalytic activity | cellular response to oxidative stress | cellular response to amino acid starvation | determination of bilateral symmetry | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | response to lipid | regulation of stem cell proliferation | regulation of DNA replication origin binding | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of protein complex assembly | regulation of cellular component movement | response to oxidative stress | negative regulation of binding | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of cell migration | response to cadmium ion | response to osmotic stress | stress-activated MAPK cascade | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | MAP kinase activity | phosphorylation | protein localization to cell junction | positive regulation of neuron death | response to toxic substance | regulation of apoptotic signaling pathway | regulation of cyclase activity | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | regulation of muscle cell apoptotic process | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein deacetylation | regulation of neuron apoptotic process | inflammatory response | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | neuronal stem cell population maintenance | regulation of microtubule-based process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | neuron differentiation | regulation of podosome assembly | protein localization to tricellular tight junction | protein metabolic process | regionalization | positive regulation of protein modification process | response to organic substance | cellular response to reactive nitrogen species | response to mechanical stimulus | positive regulation of neuron apoptotic process | anatomical structure development | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | positive regulation of cell development | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | cellular response to hydrogen peroxide | positive regulation of cell death | positive regulation of determination of dorsal identity | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | positive regulation of neuron migration | positive regulation of cellular component biogenesis | organic substance metabolic process | maintenance of cell number | cell death | response to reactive oxygen species | positive regulation of programmed cell death | response to heat | regulation of chromosome organization | dendrite morphogenesis | positive regulation of cardiac muscle cell apoptotic process | regulation of cell communication | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of protein binding | cell development | determination of dorsal identity | protein localization | cellular protein metabolic process | enzyme regulator activity | anatomical structure morphogenesis | positive regulation of stem cell proliferation | protein serine/threonine/tyrosine kinase activity | response to biotic stimulus | regulation of circadian rhythm | dendrite development | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | positive regulation of DNA metabolic process | kinase activity | developmental process | peptidyl-serine phosphorylation | cellular protein modification process | necrotic cell death | positive regulation of protein polymerization | regulation of histone deacetylation | response to amino acid starvation | positive regulation of metabolic process | ossification | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | response to nitric oxide | regulation of organelle assembly | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | determination of dorsal/ventral asymmetry | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | basal dendrite | cell body | cell | neuronal cell body | cytoplasm | dendrite cytoplasm | intracellular organelle | actin cytoskeleton | dendritic tree | protein-containing complex | cell projection | plasma membrane bounded cell projection cytoplasm | perikaryon | vesicle | podosome | cytoplasmic region | mitochondrion | membrane-bounded organelle | nucleus | organelle | axon | cytosol | cytoskeleton | intracellular
