QuickView for MPK3;jsessionid=4F84EA000D7104EF72EC3216B0946177;jsessionid=53F3615B5C06B71C1F97E2358F6887E9 (gene)

Gene Symbol:

MAP2K3 Homo sapiens

Full name:

mitogen-activated protein kinase kinase 3

Synonyms:

MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPK/ERK kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, stress-activated protein kinase kinase 2

Genomic Location:

Chr 17: 21128561-21159145

Description:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is neces...

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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  HNF4ALPHA_Q6 ,  CEBPA_01 ,  TTANTCA_UNKNOWN ,  E4BP4_01 ,  CEBP_Q2_01 ,  STAT6_01 ,  TTAYRTAA_E4BP4_01 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  STAT5B_01 ,  DR1_Q3 ,  GGGCGGR_SP1_Q6 ,  CREBP1_01 ,  GTGCCAA_MIR96 ,  TGTTTGY_HNF3_Q6 ,  STAT_01 ,  HMGIY_Q6 ,  CEBP_Q3 ,  CEBP_C ,  COUP_DR1_Q6 ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  PPAR_DR1_Q2 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

17p11.2

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