QuickView for Mars;jsessionid=F854A1B16BD6DD2FB0E28EEA2737053C (gene)

Gene Symbol:

Mars Mus musculus

Full name:

methionine-tRNA synthetase

Synonyms:

Metrs, Mtrns, methionine--tRNA ligase, cytoplasmic, methionine tRNA ligase, methionyl-tRNA synthetase, cytoplasmic

Genomic Location:

Chr 10: 126733282-126748695

Description:

The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inh...

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The encoded protein belongs to the class I family of tRNA synthetases, a class of enzymes that charge tRNAs with their cognate amino acids. The related human gene product is essential for the translation initiation of mRNAs. This gene has an overlapping 3' UTR tail-to-tail arrangement with an adjacent gene on the opposite strand that encodes an inhibitor of the CCAAT/enhancer-binding protein's DNA binding activity. This arrangement, conserved in human and mouse, may be involved in mRNA stability and possible functional and regulatory interaction of these adjacent overlapping genes. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ELK1_02 ,  AACYNNNNTTCCS_UNKNOWN ,  STAT1_02 ,  STAT1_03 ,  CEBPGAMMA_Q6 ,  FOXM1_01 ,  NRF1_Q6 ,  AR_Q6 ,  RACTNNRTTTNC_UNKNOWN ,  TGCGCANK_UNKNOWN ,  SCGGAAGY_ELK1_02 ,  RCGCANGCGY_NRF1_Q6 ,  TCANNTGAY_SREBP1_01

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