QuickView for Mdm2;jsessionid=E942FB8AD44C020E1FB668343311C82F;jsessionid=F47E3AE134D2C75217DAD07A9669D0A8 (gene)
- Gene Symbol:
- MDM2
Canis lupus familiaris - Full name:
- Mdm2 p53 binding protein homolog (mouse)
- Synonyms:
- N/A
- Genomic Location:
- Chr 10: 13920600-13946519
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
NEDD8 transferase activity | cation binding | enzyme binding | nucleic acid binding | protein-containing complex binding | disordered domain specific binding | 5S rRNA binding | ubiquitin binding | catalytic activity | ribonucleoprotein complex binding | protein domain specific binding | protein N-terminus binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | p53 binding | identical protein binding | ubiquitin protein ligase activity | ubiquitin-like protein binding | scaffold protein binding | ion binding | organic cyclic compound binding | protein binding | zinc ion binding | ubiquitin protein ligase binding | NEDD8 ligase activity | ligase activity | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | metal ion binding | heterocyclic compound binding | rRNA binding | RNA binding
GO Biological Process
response to radiation | regulation of cell cycle process | cellular response to decreased oxygen levels | intracellular signal transduction | proteolysis | regulation of cell cycle G1/S phase transition | positive regulation of G1/S transition of mitotic cell cycle | regulation of programmed cell death | peptidyl-amino acid modification | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | response to antibiotic | mesenchyme development | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | mitotic DNA integrity checkpoint | regulation of DNA damage response, signal transduction by p53 class mediator | tissue remodeling | heart morphogenesis | negative regulation of signaling | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cell cycle arrest | negative regulation of cellular metabolic process | tissue development | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | positive regulation of cell cycle phase transition | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | signal transduction involved in mitotic DNA damage checkpoint | cellular component organization | positive regulation of cellular protein catabolic process | response to stimulus | vasculature development | regulation of mitotic cell cycle phase transition | blood vessel remodeling | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | cellular response to hypoxia | response to stress | regulation of blood circulation | response to peptide | protein localization to nucleus | regulation of cell cycle phase transition | response to actinomycin D | protein destabilization | supramolecular fiber organization | positive regulation of proteolysis involved in cellular protein catabolic process | regulation of heart rate | cellular protein catabolic process | atrioventricular valve morphogenesis | cellular localization | cardiovascular system development | positive regulation of proteolysis | negative regulation of metabolic process | cellular component assembly | protein modification process | macromolecule modification | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | blood vessel development | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | cellular response to actinomycin D | endocardial cushion development | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | regulation of protein stability | cellular response to antibiotic | mitotic DNA damage checkpoint | multicellular organism development | cellular response to DNA damage stimulus | regulation of intrinsic apoptotic signaling pathway | amyloid fibril formation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cellular response to peptide | cell cycle | protein catabolic process | endocardial cushion morphogenesis | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | cellular response to radiation | animal organ morphogenesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of signal transduction by p53 class mediator | cardiac atrium development | regulation of transcription by RNA polymerase II | cellular response to gamma radiation | ubiquitin protein ligase activity | protein localization to organelle | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | mesenchyme morphogenesis | cardiac septum morphogenesis | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | regulation of heart contraction | positive regulation of cell cycle G1/S phase transition | response to gamma radiation | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | heart development | regulation of RNA metabolic process | regulation of mitotic cell cycle | regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of cell cycle arrest | protein-containing complex assembly | heart valve development | ventricular septum development | protein metabolic process | cardiac ventricle development | response to organic substance | protein ubiquitination | G1 DNA damage checkpoint | tissue morphogenesis | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | protein autoubiquitination | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of mitotic cell cycle | cellular protein localization | peptidyl-lysine modification | regulation of response to DNA damage stimulus | heart valve morphogenesis | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | cellular response to ionizing radiation | establishment of protein localization | atrioventricular valve development | atrial septum development | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | signal transduction involved in DNA damage checkpoint | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | traversing start control point of mitotic cell cycle | positive regulation of cell cycle process | cardiac septum development | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | response to organonitrogen compound | cardiac chamber development | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | response to ionizing radiation | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
