QuickView for Mre11;jsessionid=66AD74BD502FA3EEE82E5172B75FB0F1;jsessionid=A0AB66E6B40FEA1D021E6C47E3D5E8B2 (gene)
- Gene Symbol:
- Mre11a
Mus musculus - Full name:
- MRE11A homolog A, double strand break repair nuclease
- Synonyms:
- Mre11, Mre11b, double-strand break repair protein MRE11, double-strand break repair protein MRE11A, MRE11 homolog 1, MRE11 homolog A, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A, mmMRE11A
- Genomic Location:
- Chr 9: 14589151-14638863
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
| Transcripts Names |
|---|
| NM_018736 |
| XM_006510054 |
| XM_006510053 |
| NM_001310728 |
| XM_006510052 |
| XM_006510049 |
| XR_379107 |
| XM_006510051 |
| XM_006510048 |
GO Molecular Function
sequence-specific DNA binding | nuclease activity | sequence-specific single stranded DNA binding | single-stranded DNA endodeoxyribonuclease activity | cation binding | nucleic acid binding | ATP-dependent DNA helicase activity | hydrolase activity | single-stranded DNA binding | ATPase activity | pyrophosphatase activity | catalytic activity | nucleoside-triphosphatase activity | ATPase activity, coupled | deoxyribonuclease activity | DNA binding | hydrolase activity, acting on ester bonds | identical protein binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | double-stranded telomeric DNA binding | endodeoxyribonuclease activity | DNA helicase activity | protein binding | double-stranded DNA binding | manganese ion binding | 3'-5' exonuclease activity | hydrolase activity, acting on acid anhydrides | endonuclease activity | transition metal ion binding | single-stranded telomeric DNA binding | DNA-dependent ATPase activity | helicase activity | exonuclease activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | telomeric DNA binding | protein C-terminus binding
GO Biological Process
double-strand break repair | intra-S DNA damage checkpoint | regulation of cell cycle process | telomere maintenance | positive regulation of cellular component organization | nuclease activity | regulation of programmed cell death | negative regulation of cellular process | telomere capping | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | cellular process | synapsis | single-stranded DNA endodeoxyribonuclease activity | mitotic DNA integrity checkpoint | negative regulation of viral life cycle | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | DNA geometric change | anatomical structure homeostasis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | ATP-dependent DNA helicase activity | negative regulation of DNA replication | response to stimulus | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint | regulation of cell cycle phase transition | reproduction | cellular nitrogen compound metabolic process | telomere organization | double-strand break repair via nonhomologous end joining | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | DNA recombination | meiotic chromosome segregation | DNA repair | regulation of cell cycle G2/M phase transition | regulation of viral entry into host cell | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | mitotic DNA damage checkpoint | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | regulation of phosphorylation | positive regulation of chromosome organization | cellular response to stress | cell cycle | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | deoxyribonuclease activity | mitochondrial double-strand break repair via homologous recombination | regulation of nitrogen compound metabolic process | regulation of DNA endoreduplication | negative regulation of viral process | cell proliferation | regulation of cellular protein metabolic process | regulation of DNA-dependent DNA replication | DNA duplex unwinding | nuclear chromosome segregation | DNA strand elongation | regulation of cellular metabolic process | negative regulation of DNA endoreduplication | endodeoxyribonuclease activity | regulation of protein metabolic process | base-excision repair | homeostatic process | regulation of protein phosphorylation | meiotic DNA double-strand break formation | regulation of viral process | regulation of mitotic cell cycle | DNA helicase activity | positive regulation of molecular function | mitotic G2/M transition checkpoint | homologous chromosome segregation | positive regulation of protein modification process | negative regulation of viral entry into host cell | telomeric 3' overhang formation | negative regulation of DNA-dependent DNA replication | regulation of kinase activity | DNA metabolic process | mitotic cell cycle | nuclear division | metabolic process | 3'-5' exonuclease activity | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | endonuclease activity | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of chromosome organization | chromosome organization involved in meiotic cell cycle | meiosis I | negative regulation of cell cycle | meiotic cell cycle | positive regulation of phosphorylation | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | recombinational repair | organelle organization | sister chromatid cohesion | positive regulation of protein autophosphorylation | exonuclease activity | DNA conformation change | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | regulation of viral life cycle | negative regulation of cell death | regulation of cellular component organization | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
condensed nuclear chromosome | site of DNA damage | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear chromosome | perinuclear region of cytoplasm | chromosome, telomeric region | site of double-strand break | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | nuclear chromosome, telomeric region | intracellular | Mre11 complex | condensed chromosome
