QuickView for Mre11;jsessionid=66AD74BD502FA3EEE82E5172B75FB0F1;jsessionid=33E2A37A0A5249703A4A5942F2AB475B (gene)
- Gene Symbol:
- Mre11a
Rattus norvegicus - Full name:
- MRE11 homolog A, double strand break repair nuclease
- Synonyms:
- Mre11, double-strand break repair protein MRE11, double-strand break repair protein MRE11A, MRE11 homolog 1, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A
- Genomic Location:
- Chr 8: 11588409-11632483
- Description:
-
may play a role in regulation of cardiomyocyte proliferation
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | nuclease activity | sequence-specific single stranded DNA binding | single-stranded DNA endodeoxyribonuclease activity | cation binding | nucleic acid binding | ATP-dependent DNA helicase activity | hydrolase activity | single-stranded DNA binding | ATPase activity | pyrophosphatase activity | catalytic activity | nucleoside-triphosphatase activity | ATPase activity, coupled | deoxyribonuclease activity | DNA binding | hydrolase activity, acting on ester bonds | identical protein binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | double-stranded telomeric DNA binding | endodeoxyribonuclease activity | DNA helicase activity | protein binding | double-stranded DNA binding | manganese ion binding | 3'-5' exonuclease activity | hydrolase activity, acting on acid anhydrides | endonuclease activity | transition metal ion binding | single-stranded telomeric DNA binding | DNA-dependent ATPase activity | helicase activity | exonuclease activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | telomeric DNA binding | protein C-terminus binding
GO Biological Process
double-strand break repair | intra-S DNA damage checkpoint | regulation of cell cycle process | telomere maintenance | positive regulation of cellular component organization | nuclease activity | regulation of programmed cell death | negative regulation of cellular process | telomere capping | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | cellular process | synapsis | single-stranded DNA endodeoxyribonuclease activity | mitotic DNA integrity checkpoint | negative regulation of viral life cycle | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | DNA geometric change | anatomical structure homeostasis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | ATP-dependent DNA helicase activity | negative regulation of DNA replication | response to stimulus | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | mitotic G2 DNA damage checkpoint | regulation of cell cycle phase transition | reproduction | cellular nitrogen compound metabolic process | telomere organization | double-strand break repair via nonhomologous end joining | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | DNA recombination | meiotic chromosome segregation | DNA repair | regulation of cell cycle G2/M phase transition | system development | regulation of viral entry into host cell | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | regulation of phosphorylation | positive regulation of chromosome organization | cellular response to stress | cell cycle | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | deoxyribonuclease activity | mitochondrial double-strand break repair via homologous recombination | regulation of nitrogen compound metabolic process | regulation of DNA endoreduplication | negative regulation of viral process | cell proliferation | regulation of cellular protein metabolic process | regulation of DNA-dependent DNA replication | DNA duplex unwinding | nuclear chromosome segregation | DNA strand elongation | regulation of cellular metabolic process | negative regulation of DNA endoreduplication | endodeoxyribonuclease activity | regulation of protein metabolic process | base-excision repair | heart development | homeostatic process | regulation of protein phosphorylation | meiotic DNA double-strand break formation | regulation of viral process | regulation of mitotic cell cycle | DNA helicase activity | positive regulation of molecular function | mitotic G2/M transition checkpoint | homologous chromosome segregation | positive regulation of protein modification process | negative regulation of viral entry into host cell | telomeric 3' overhang formation | negative regulation of DNA-dependent DNA replication | regulation of kinase activity | DNA metabolic process | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | 3'-5' exonuclease activity | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | endonuclease activity | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of chromosome organization | chromosome organization involved in meiotic cell cycle | meiosis I | negative regulation of cell cycle | meiotic cell cycle | positive regulation of phosphorylation | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | recombinational repair | developmental process | organelle organization | sister chromatid cohesion | positive regulation of protein autophosphorylation | exonuclease activity | DNA conformation change | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | DNA damage checkpoint | cell cycle checkpoint | regulation of viral life cycle | negative regulation of cell death | circulatory system development | regulation of cellular component organization | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
condensed nuclear chromosome | site of DNA damage | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear chromosome | perinuclear region of cytoplasm | chromosome, telomeric region | site of double-strand break | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | nuclear chromosome, telomeric region | intracellular | Mre11 complex | condensed chromosome
