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QuickView for NANOG;jsessionid=4095376D6EC92E603BC1A095894E83F9;jsessionid=5BA6726176005E5469306E42D867B1F4 (gene)


Gene Symbol:
Nanog Mus musculus Mus musculus
Full name:
Nanog homeobox
Synonyms:
2410002E02Rik, ENK, ecat4, homeobox protein NANOG, ES cell-associated protein 4, early embryo specific expression NK family, early embryo specific expression NK-type homeobox protein, homeobox transcription factor Nanog
Genomic Location:
Chr 6: 122657611-122664651
Description:
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Several transcript variants encoding different isoforms have been f...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | chromatin binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | identical protein binding | organic cyclic compound binding | RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | RNA polymerase II sequence-specific DNA-binding transcription factor binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | negative regulation of embryonic development | developmental process involved in reproduction | somatic stem cell population maintenance | gonad development | negative regulation of BMP signaling pathway | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | mesoderm morphogenesis | negative regulation of signaling | reproductive system development | mesoderm development | regulation of embryonic development | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | negative regulation of endodermal cell differentiation | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of cell division | development of primary sexual characteristics | response to stimulus | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | mesoderm formation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | reproduction | cellular nitrogen compound metabolic process | regulation of stem cell population maintenance | endodermal cell fate commitment | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | embryo development | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | cell dedifferentiation | multicellular organism development | regulation of BMP signaling pathway | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of cell fate specification | response to lipid | negative regulation of endodermal cell fate specification | stem cell division | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of cellular response to growth factor stimulus | transcription corepressor activity | regulation of transcription by RNA polymerase II | endoderm formation | stem cell differentiation | cell proliferation | biosynthetic process | cell division | aromatic compound biosynthetic process | endodermal cell fate specification | mesodermal cell fate commitment | regulation of cellular metabolic process | positive regulation of cell proliferation | regulation of RNA metabolic process | response to retinoic acid | regulation of cellular response to growth factor stimulus | negative regulation of cell fate commitment | embryonic morphogenesis | regulation of mitotic cell cycle | negative regulation of cell fate specification | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | tissue morphogenesis | anatomical structure development | regulation of endodermal cell fate specification | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of endodermal cell differentiation | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | reproductive structure development | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | regulation of gastrulation | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of cell fate commitment | mesodermal cell differentiation | positive regulation of metabolic process | gastrulation | cellular metabolic process | regulation of stem cell division | sex differentiation | negative regulation of cell differentiation | regulation of signaling | positive regulation of gene expression | embryonic pattern specification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | condensed chromosome