QuickView for NAT2;jsessionid=5778841256BCCB161C92FE9502EE5BFA;jsessionid=81139728151057C13C6CEC8FC926220C;jsessionid=E1EB099C2C669C33A45AD10C0F60A276;jsessionid=DF9507562174D672220A81A646712F30;jsessionid=9D14A5D26730DBAB831ABD9D158AF21C (gene)

Gene Symbol:

NAT2 Homo sapiens

Full name:

N-acetyltransferase 2

Synonyms:

AAC2, NAT-2, PNAT, arylamine N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, arylamide acetylase 2

Genomic Location:

Chr 8: 18293035-18303003

Description:

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with hig...

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This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

8p22

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