QuickView for NOD2;jsessionid=D2B2803848631C6706696A45CB435EAD;jsessionid=AEA021859AD1262AD2736915D121B068;jsessionid=60012AD67660AF867DA7E2ABE4F6B462 (gene)
- Gene Symbol:
- Nod2
Mus musculus - Full name:
- nucleotide-binding oligomerization domain containing 2
- Synonyms:
- ACUG, BLAU, CD, Card15, F830032C23Rik, IBD1, Nlrc2, nucleotide-binding oligomerization domain-containing protein 2, caspase recruitment domain family, member 15, caspase recruitment domain-containing protein 15
- Genomic Location:
- Chr 8: 91171246-91212373
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
actin binding | kinase binding | nuclease activity | peptide binding | protein kinase binding | muramyl dipeptide binding | enzyme binding | ribonucleotide binding | nucleotide binding | CARD domain binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | protein domain specific binding | ATP binding | Hsp70 protein binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | deoxyribonuclease activity | amide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | ion binding | organic cyclic compound binding | endodeoxyribonuclease activity, producing 5'-phosphomonoesters | endodeoxyribonuclease activity | purine ribonucleoside triphosphate binding | protein binding | peptidoglycan binding | glycosaminoglycan binding | endonuclease activity | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | Hsp90 protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | regulation of leukocyte chemotaxis | nucleotide-binding oligomerization domain containing signaling pathway | regulation of ERK1 and ERK2 cascade | regulation of T cell mediated immunity | regulation of interleukin-1 beta production | adaptive immune response | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | detection of stimulus | cellular response to muramyl dipeptide | positive regulation of cellular component organization | regulation of B cell activation | immune response-regulating signaling pathway | response to lipopolysaccharide | intracellular signal transduction | regulation of localization | nuclease activity | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | defense response to other organism | establishment of localization | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | regulation of MAP kinase activity | epithelial structure maintenance | positive regulation of lymphocyte activation | positive regulation of epithelial cell proliferation | positive regulation of prostaglandin-E synthase activity | positive regulation of antimicrobial humoral response | negative regulation of growth of symbiont involved in interaction with host | defense response | response to drug | positive regulation of interleukin-1 beta secretion | positive regulation of phosphate metabolic process | positive regulation of protein secretion | tissue homeostasis | positive regulation of phosphatidylinositol 3-kinase activity | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | secretion | response to exogenous dsRNA | negative regulation of inflammatory response | regulation of cell motility | localization | protein transport | positive regulation of humoral immune response mediated by circulating immunoglobulin | negative regulation of signaling | positive regulation of immune effector process | positive regulation of adaptive immune response | positive regulation of protein kinase activity | macromolecule localization | regulation of chemotaxis | negative regulation of apoptotic process | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | anatomical structure homeostasis | positive regulation of interleukin-8 production | positive regulation of dendritic cell antigen processing and presentation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of antibacterial peptide biosynthetic process | cellular response to molecule of bacterial origin | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | positive regulation of antigen processing and presentation | cellular component organization | positive regulation of dendritic cell cytokine production | regulation of neutrophil chemotaxis | negative regulation of toll-like receptor signaling pathway | positive regulation of tumor necrosis factor production | positive regulation of interleukin-17 production | positive regulation of antimicrobial peptide production | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of interleukin-1 beta production | positive regulation of NIK/NF-kappaB signaling | positive regulation of innate immune response | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | cellular response to peptidoglycan | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | detection of peptidoglycan | regulation of antimicrobial humoral response | regulation of cell proliferation | positive regulation of protein polyubiquitination | multicellular organismal homeostasis | regulation of protein ubiquitination | negative regulation of interferon-gamma production | response to peptide | regulation of humoral immune response mediated by circulating immunoglobulin | response to muramyl dipeptide | regulation of humoral immune response | positive regulation of cell activation | activation of innate immune response | secretion by cell | positive regulation of cytokine secretion | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | regulation of macroautophagy | nucleic acid phosphodiester bond hydrolysis | regulation of phagocytosis | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | regulation of peptide transport | regulation of phosphatidylinositol 3-kinase activity | negative regulation of toll-like receptor 2 signaling pathway | negative regulation of adaptive immune response | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | negative regulation of NF-kappaB transcription factor activity | regulation of cellular response to stress | response to nitrogen compound | negative regulation of macrophage apoptotic process | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | regulation of macrophage apoptotic process | response to external biotic stimulus | detection of molecule of bacterial origin | nitrogen compound metabolic process | regulation of signal transduction | detection of chemical stimulus | pattern recognition receptor signaling pathway | negative regulation of growth | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | positive regulation of inflammatory response | response to dsRNA | protein complex oligomerization | leukocyte mediated immunity | maintenance of gastrointestinal epithelium | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of gene expression | macrophage inflammatory protein-1 alpha production | positive regulation of secretion | organic substance transport | response to lipid | cellular response to peptide | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | digestive system process | regulation of lymphocyte activation | deoxyribonuclease activity | response to peptidoglycan | positive regulation of Notch signaling pathway | regulation of defense response to bacterium | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of Notch signaling pathway | positive regulation of JNK cascade | positive regulation of interleukin-12 production | peptide transport | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | positive regulation of humoral immune response | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cytokine production involved in inflammatory response | detection of muramyl dipeptide | negative regulation of interleukin-12 production | regulation of cytokine production involved in inflammatory response | regulation of cellular protein metabolic process | positive regulation of immunoglobulin mediated immune response | positive regulation of monocyte chemotactic protein-1 production | negative regulation of immune response | positive regulation of interleukin-1 secretion | regulation of antimicrobial peptide biosynthetic process | positive regulation of chemokine production | cytokine production involved in immune response | regulation of tumor necrosis factor production | regulation of leukocyte migration | cellular response to drug | response to bacterium | regulation of lipid kinase activity | regulation of interleukin-1 production | endodeoxyribonuclease activity, producing 5'-phosphomonoesters | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of interleukin-1 production | inflammatory response | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | endodeoxyribonuclease activity | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of interleukin-2 production | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of defense response to bacterium | positive regulation of B cell activation | positive regulation of transport | regulation of phospholipid metabolic process | cytokine secretion involved in immune response | nucleotide-binding oligomerization domain containing 2 signaling pathway | positive regulation of molecular function | regulation of cytokine secretion | cytokine production | positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | regulation of establishment of protein localization | positive regulation of type 2 immune response | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of innate immune response | chemokine production | positive regulation of xenophagy | regulation of kinase activity | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | metabolic process | cytokine secretion | negative regulation of growth of symbiont in host | regulation of neutrophil migration | immunoglobulin production involved in immunoglobulin mediated immune response | regulation of interleukin-1 beta secretion | immunoglobulin production | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | amide transport | regulation of vesicle-mediated transport | regulation of secretion | regulation of myeloid cell apoptotic process | positive regulation of interleukin-6 production | regulation of protein K63-linked ubiquitination | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | endonuclease activity | positive regulation of kinase activity | positive regulation of phagocytosis | negative regulation of interleukin-18 production | detection of bacterium | positive regulation of prostaglandin-endoperoxide synthase activity | regulation of phosphate metabolic process | regulation of dendritic cell cytokine production | positive regulation of protein K63-linked ubiquitination | negative regulation of T cell mediated immunity | positive regulation of autophagy | establishment of protein localization | positive regulation of cytokine production | positive regulation of macroautophagy | regulation of JNK cascade | positive regulation of MAPK cascade | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | intracellular receptor signaling pathway | positive regulation of protein transport | regulation of antimicrobial peptide production | defense response to Gram-positive bacterium | regulation of stress-activated MAPK cascade | regulation of cell communication | positive regulation of interleukin-10 production | negative regulation of molecular function | negative regulation of signal transduction | regulation of antigen processing and presentation | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | regulation of endocytosis | protein localization | regulation of epithelial cell proliferation | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | B cell mediated immunity | detection of biotic stimulus | positive regulation of antibacterial peptide production | digestion | mucosal immune response | regulation of monocyte chemotactic protein-1 production | regulation of chemokine production | regulation of transport | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of lipid kinase activity | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of antimicrobial peptide biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | regulation of interferon-gamma production | immunoglobulin mediated immune response | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | negative regulation of inflammatory response to antigenic stimulus | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | innate immune response in mucosa | positive regulation of endocytosis | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | COP9 signalosome | cell | cytoplasm | intracellular organelle | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | vesicle | membrane-bounded organelle | nucleus | organelle | cell periphery | basolateral plasma membrane | cytosol | cell surface | cytoskeleton | intracellular | membrane
