QuickView for NOS2;jsessionid=625F01E7C0E1D0BBC0AA1E54835EC2EC;jsessionid=38518E2FEA31287D0D1EEC7BB7A05231;jsessionid=A64D27746390CF963A4B77714CA50FFD;jsessionid=551D54F79030F65112E1013D43168BC0 (gene)
- Gene Symbol:
- Nos2
Mus musculus - Full name:
- nitric oxide synthase 2, inducible
- Synonyms:
- MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS, nitric oxide synthase, inducible, NOS type II, inducible NO synthase, inducible NOS, inducible nitric oxide synthase, macrophage NOS, nitric oxide synthase 2, inducible, macrophage, peptidyl-cysteine S-nitrosylase NOS2
- Genomic Location:
- Chr 11: 78734361-78773626
- Description:
-
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms ...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
beta-catenin binding | actin binding | oxidoreductase activity, acting on NAD(P)H | kinase binding | NADP binding | protein kinase regulator activity | cofactor binding | cadherin binding | cation binding | kinase regulator activity | protein kinase binding | carboxylic acid binding | enzyme binding | ribonucleotide binding | FMN binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | signaling receptor binding | carbohydrate derivative binding | molecular function regulator | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | cytoskeletal protein binding | anion binding | amino acid binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | identical protein binding | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | ion binding | organic cyclic compound binding | tetrahydrobiopterin binding | cAMP-dependent protein kinase regulator activity | cell adhesion molecule binding | tetrapyrrole binding | protein binding | protein homodimerization activity | arginine binding | nitric-oxide synthase activity | protein dimerization activity | nitric-oxide synthase binding | NADPH-hemoprotein reductase activity | Hsp90 protein binding | enzyme regulator activity | heme binding | drug binding | calmodulin binding | heat shock protein binding | organic acid binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
positive regulation of cyclase activity | positive regulation of cell killing | oxidoreductase activity, acting on NAD(P)H | response to cytokine | response to lipopolysaccharide | developmental process involved in reproduction | positive regulation of lyase activity | intracellular signal transduction | regulation of localization | protein kinase regulator activity | gonad development | lipid transport | female gonad development | peptidyl-amino acid modification | superoxide metabolic process | defense response to other organism | nitric oxide biosynthetic process | establishment of localization | response to hormone | defense response | response to drug | reactive oxygen species metabolic process | positive regulation of phosphate metabolic process | interleukin-6 secretion | regulation of peptide hormone secretion | positive regulation of cellular biosynthetic process | cellular amino acid catabolic process | cellular process | secretion | organic substance catabolic process | monocarboxylic acid transport | localization | protein transport | kinase regulator activity | reproductive system development | positive regulation of killing of cells of other organism | anion transport | multicellular organismal reproductive process | macromolecule localization | response to hypoxia | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | prostaglandin transport | gamete generation | cellular amino acid metabolic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | cellular response to molecule of bacterial origin | interleukin-8 production | cellular response to interferon-gamma | development of primary sexual characteristics | regulation of peptide secretion | response to stimulus | ovulation | female gamete generation | acid secretion | regulation of insulin secretion | carboxylic acid catabolic process | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | circadian rhythm | development of primary female sexual characteristics | reproduction | secretion by cell | rhythmic process | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of guanylate cyclase activity | cellular response to organic cyclic compound | regulation of protein transport | blood circulation | negative regulation of metabolic process | protein modification process | reactive oxygen species biosynthetic process | regulation of peptide transport | cellular biosynthetic process | ovulation from ovarian follicle | macromolecule modification | molecular function regulator | negative regulation of blood pressure | regulation of neurotransmitter levels | positive regulation of guanylate cyclase activity | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | multicellular organism development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | regulation of catalytic activity | regulation of killing of cells of other organism | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | nitric oxide mediated signal transduction | regulation of gene expression | fatty acid transport | prostaglandin secretion | organic substance transport | response to lipid | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | regulation of blood pressure | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | peptide transport | organic acid transport | second-messenger-mediated signaling | neurotransmitter metabolic process | cellular response to cytokine stimulus | interleukin-8 secretion | regulation of cytokine production involved in inflammatory response | biosynthetic process | regulation of cellular protein metabolic process | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | organic anion transport | interleukin-6 production | regulation of cyclase activity | ovulation cycle process | cellular response to drug | response to bacterium | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | cAMP-dependent protein kinase regulator activity | inflammatory response | regulation of protein metabolic process | defense response to bacterium | arginine catabolic process | regulation of protein phosphorylation | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | multicellular organism reproduction | cytokine production | reactive nitrogen species metabolic process | protein metabolic process | regulation of establishment of protein localization | response to organic substance | nitric-oxide synthase activity | regulation of kinase activity | peptidyl-cysteine S-nitrosylation | anatomical structure development | metabolic process | lipid localization | cytokine secretion | regulation of protein catabolic process | oxidation-reduction process | amide transport | regulation of secretion | immune response | organic substance metabolic process | negative regulation of gene expression | animal organ development | regulation of protein secretion | protein nitrosylation | regulation of phosphate metabolic process | establishment of protein localization | response to interferon-gamma | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | neurotransmitter biosynthetic process | regulation of cell communication | arginine metabolic process | NADPH-hemoprotein reductase activity | signaling | response to organic cyclic compound | protein localization | organic acid metabolic process | cellular protein metabolic process | enzyme regulator activity | carboxylic acid transport | regulation of cytokine production | response to biotic stimulus | reproductive structure development | developmental process | nitric oxide metabolic process | cellular protein modification process | regulation of transport | innate immune response | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | female sex differentiation | cellular response to organic substance | regulation of protein localization | sex differentiation | protein secretion | oxidoreductase activity | regulation of inflammatory response | sexual reproduction | response to other organism | signal transduction | regulation of signaling | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | cytoplasm | cortical cytoskeleton | intracellular organelle | plasma membrane | vesicle | perinuclear region of cytoplasm | cytoplasmic region | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | vesicle membrane | extracellular space | cell periphery | cytosol | cytoskeleton | intracellular | membrane
