QuickView for Nox;jsessionid=8C45C722315ADA2C63A0EEB2B8DCAE66;jsessionid=32E0294AC825FEE6690A74826E9D3219;jsessionid=BC21B515B9B058C0D69B5DEA6E3984DE;jsessionid=9F2D7D9828EDC0A90378FC8BB562F8C5;jsessionid=3AA6A39905F82312BBEB291AF9C5A41C (gene)
- Gene Symbol:
- NOX5
Homo sapiens - Full name:
- NADPH oxidase 5
- Synonyms:
- NADPH oxidase 5, NADPH oxidase, EF-hand calcium binding domain 5
- Genomic Location:
- Chr 15: 67009918-67136127
- Description:
-
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encod...
- Orthologs:
- Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , D. melanogaster , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
15q23
GO Molecular Function
oxidoreductase activity, acting on NAD(P)H | NADP binding | cofactor binding | proton transmembrane transporter activity | cation binding | passive transmembrane transporter activity | superoxide-generating NADPH oxidase activity | transmembrane transporter activity | proton channel activity | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | anion binding | cation transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | tetrapyrrole binding | cation channel activity | calcium ion binding | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | channel activity | heme binding | metal ion binding | ion channel activity | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | heterocyclic compound binding | oxidoreductase activity | substrate-specific channel activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on NAD(P)H | regulation of localization | superoxide metabolic process | establishment of localization | proton transmembrane transporter activity | reactive oxygen species metabolic process | blood vessel morphogenesis | cellular process | secretion | proton transmembrane transport | localization | protein transport | passive transmembrane transporter activity | cytoskeleton-dependent cytokinesis | superoxide-generating NADPH oxidase activity | macromolecule localization | endothelial cell proliferation | regulation of cellular process | transmembrane transporter activity | proton channel activity | superoxide anion generation | response to stimulus | vasculature development | response to stress | tube morphogenesis | programmed cell death | secretion by cell | cardiovascular system development | blood vessel development | regulation of fertilization | apoptotic process | regulation of fusion of sperm to egg plasma membrane | regulation of proton transport | system development | multicellular organism development | cellular response to oxidative stress | ion transmembrane transport | organic substance transport | cellular response to stress | cell cycle | cation transmembrane transporter activity | monovalent inorganic cation transport | peptide transport | response to oxidative stress | ion transmembrane transporter activity | cell proliferation | cell division | angiogenesis | cytokinesis | peptide secretion | cation transmembrane transport | cytokine production | epithelial cell proliferation | anatomical structure development | metabolic process | cytokine secretion | oxidation-reduction process | amide transport | cell death | inorganic cation transmembrane transport | regulation of ion transmembrane transport | establishment of protein localization | cation channel activity | anatomical structure formation involved in morphogenesis | transmembrane transport | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | protein localization | anatomical structure morphogenesis | cation transport | channel activity | regulation of ion transport | developmental process | tube development | regulation of transport | ion channel activity | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | ion transport | cellular metabolic process | protein secretion | oxidoreductase activity | circulatory system development | substrate-specific channel activity | regulation of cellular component organization | multicellular organismal process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
