QuickView for OPTN;jsessionid=005971FBE9928DAC8897112ECFE42B2E;jsessionid=B74A72D802DDDACFBAB88941AF5E7C46;jsessionid=6912787DDA4D4C6D1953247C1FD55B8E (gene)
- Gene Symbol:
- Optn
Rattus norvegicus - Full name:
- optineurin
- Synonyms:
- Fip2, optineurin, 14.7K-interacting protein 2, FIP-2-like protein
- Genomic Location:
- Chr 17: 84298122-84348330
- Description:
-
an injury induced protein; human homolog may be linked to glaucoma
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
K63-linked polyubiquitin modification-dependent protein binding | GTPase binding | cation binding | enzyme binding | ubiquitin binding | Ras GTPase binding | polyubiquitin modification-dependent protein binding | protein binding, bridging | modification-dependent protein binding | identical protein binding | ubiquitin-like protein binding | ion binding | TFIIIA-class transcription factor binding | molecular adaptor activity | protein binding | transcription factor binding | small GTPase binding | Rab GTPase binding | metal ion binding | protein C-terminus binding
GO Biological Process
response to extracellular stimulus | protein homooligomerization | response to nutrient levels | response to cytokine | positive regulation of cellular component organization | protein localization to cell periphery | positive regulation of apoptotic process | regulation of programmed cell death | eye development | defense response to other organism | establishment of localization | regulation of autophagy | negative regulation of neuron death | negative regulation of cellular process | cellular response to tumor necrosis factor | defense response | cellular response to extracellular stimulus | response to drug | regulation of organelle organization | response to antibiotic | defense response to Gram-negative bacterium | regulation of neuron death | neural retina development | cellular process | secretion | localization | protein transport | negative regulation of signaling | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | macromolecule localization | negative regulation of apoptotic process | endomembrane system organization | response to growth factor | response to inorganic substance | negative regulation of cellular metabolic process | Golgi to plasma membrane transport | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | response to nerve growth factor | cellular response to unfolded protein | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular component organization | cellular response to topologically incorrect protein | positive regulation of autophagy of mitochondrion | response to stimulus | response to stress | establishment of protein localization to plasma membrane | regulation of cell proliferation | response to L-glutamate | negative regulation of receptor recycling | cellular localization | secretion by cell | cellular response to toxic substance | positive regulation of mitophagy in response to mitochondrial depolarization | regulation of macroautophagy | negative regulation of metabolic process | cellular component assembly | positive regulation of mitochondrion organization | response to nitrogen compound | negative regulation of neuron apoptotic process | response to external biotic stimulus | system development | cellular response to nutrient levels | regulation of signal transduction | positive regulation of organelle organization | cellular response to antibiotic | multicellular organism development | response to amino acid | protein complex oligomerization | cellular response to oxidative stress | cellular response to nerve growth factor stimulus | wound healing | protein localization to plasma membrane | post-Golgi vesicle-mediated transport | regulation of gene expression | protein localization to membrane | organic substance transport | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | peptide transport | vesicle-mediated transport | Golgi ribbon formation | response to nutrient | response to oxidative stress | protein localization to organelle | cellular response to cytokine stimulus | positive regulation of neuron death | response to toxic substance | cellular response to amino acid stimulus | sensory organ development | autophagy | cellular response to drug | regulation of mitochondrion organization | response to bacterium | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | defense response to bacterium | positive regulation of cell proliferation | Golgi vesicle transport | regulation of autophagy of mitochondrion | establishment of protein localization to membrane | cytokine production | protein-containing complex assembly | protein localization to Golgi apparatus | cellular response to nutrient | response to organic substance | Golgi organization | retina development in camera-type eye | positive regulation of xenophagy | response to wounding | Golgi to plasma membrane protein transport | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | regulation of neural precursor cell proliferation | metabolic process | cytokine secretion | negative regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of programmed cell death | cellular protein localization | amide transport | cellular response to hydrogen peroxide | positive regulation of cell death | cellular response to reactive oxygen species | animal organ development | response to reactive oxygen species | positive regulation of programmed cell death | positive regulation of autophagy | establishment of protein localization | positive regulation of cytokine production | positive regulation of macroautophagy | camera-type eye development | regulation of cell communication | response to mitochondrial depolarisation | negative regulation of signal transduction | protein localization | response to unfolded protein | regulation of cytokine production | cellular macromolecule localization | response to biotic stimulus | positive regulation of neural precursor cell proliferation | developmental process | organelle organization | positive regulation of mitophagy | negative regulation of cell proliferation | regulation of receptor recycling | response to organonitrogen compound | positive regulation of metabolic process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | protein secretion | negative regulation of cell death | cellular response to L-glutamate | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | response to other organism | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cytoplasmic vesicle | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | Golgi apparatus | cell projection | recycling endosome | endomembrane system | vacuole | vesicle | perinuclear region of cytoplasm | endosome | membrane-bounded organelle | nucleus | organelle | axon | trans-Golgi network | cytosol | intracellular vesicle | intracellular | autophagosome
