QuickView for P2Y12;jsessionid=1443685C7741002302F8D4215F2A88EF;jsessionid=4508E3082497D0B1A6A3DA616D424A73 (gene)
- Gene Symbol:
- P2ry12
Rattus norvegicus - Full name:
- purinergic receptor P2Y12
- Synonyms:
- P2y12, P2Y purinoceptor 12, P2Y12 platelet ADP receptor, purinergic receptor P2Y, G-protein coupled, 12
- Genomic Location:
- Chr 2: 148611035-148613985
- Description:
-
receptor activated by platelet ADP release; mediates adenylate cyclase inhibition and is a target of antithrombotic drugs
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
transmembrane signaling receptor activity | G-protein coupled purinergic nucleotide receptor activity | G-protein coupled receptor activity | signaling receptor activity | ADP receptor activity | purinergic nucleotide receptor activity | G-protein coupled adenosine receptor activity
GO Biological Process
response to extracellular stimulus | brain development | positive regulation of locomotion | response to nutrient levels | response to ATP | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | intracellular signal transduction | regulation of cell development | regulation of localization | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | purinergic nucleotide receptor signaling pathway | nervous system development | cellular response to extracellular stimulus | response to drug | neurogenesis | positive regulation of cell adhesion | positive regulation of cellular component movement | generation of neurons | response to organophosphorus | cellular process | regulation of catecholamine secretion | positive regulation of macrophage migration | regulation of cell motility | localization | forebrain cell migration | metal ion transport | positive regulation of ruffle assembly | hemostasis | regulation of chemotaxis | negative regulation of secretion | regulation of cell differentiation | regulation of protein kinase B signaling | regulation of cellular process | gliogenesis | regulation of protein complex assembly | positive regulation of cell adhesion mediated by integrin | cellular response to organonitrogen compound | cellular component organization | platelet aggregation | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled purinergic nucleotide receptor activity | positive regulation of microglial cell migration | head development | G-protein coupled receptor activity | response to stimulus | lamellipodium assembly | cerebral cortex radial glia guided migration | positive regulation of immune system process | regulation of norepinephrine secretion | response to stress | telencephalon cell migration | calcium-mediated signaling using extracellular calcium source | divalent metal ion transport | G-protein coupled purinergic nucleotide receptor signaling pathway | negative regulation of transport | positive regulation of gliogenesis | cellular response to organic cyclic compound | G-protein coupled receptor signaling pathway | cellular component assembly | regulation of cell adhesion | cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration | blood coagulation | regulation of glial cell migration | locomotion | response to nitrogen compound | protein kinase B signaling | regulation of cell projection assembly | system development | cellular response to nutrient levels | regulation of signal transduction | negative regulation of secretion by cell | multicellular organism development | cell migration | calcium ion transmembrane transport | response to purine-containing compound | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | positive regulation of protein kinase B signaling | ion transmembrane transport | wound healing | telencephalon development | positive regulation of chemotaxis | platelet activation | cellular response to ATP | cell projection assembly | response to axon injury | monovalent inorganic cation transport | positive regulation of integrin activation | regulation of cell migration | glial cell migration | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | regulation of cellular component movement | cellular potassium ion transport | response to nutrient | potassium ion transport | negative regulation of norepinephrine secretion | positive regulation of cell differentiation | second-messenger-mediated signaling | ADP receptor activity | positive regulation of cell migration | regulation of cell adhesion mediated by integrin | cerebral cortex cell migration | regulation of leukocyte migration | cellular response to drug | cell communication | positive regulation of signal transduction | regulation of locomotion | positive regulation of transport | cerebral cortex development | coagulation | negative regulation of catecholamine secretion | calcium-mediated signaling | cation transmembrane transport | lamellipodium organization | cellular response to nutrient | response to organic substance | response to wounding | regulation of intracellular signal transduction | positive regulation of integrin activation by cell surface receptor linked signal transduction | substrate-dependent cell migration | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | positive regulation of cell development | regulation of body fluid levels | calcium ion transport | regulation of secretion | cell adhesion | regulation of ruffle assembly | positive regulation of cellular component biogenesis | adenosine receptor signaling pathway | animal organ development | positive regulation of ion transport | cerebral cortex radially oriented cell migration | forebrain development | pallium development | positive regulation of leukocyte migration | regulation of integrin activation | inorganic cation transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | cell-cell adhesion | cell activation | positive regulation of glial cell migration | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | regulation of gliogenesis | transmembrane transport | signaling | response to organic cyclic compound | cation transport | positive regulation of plasma membrane bounded cell projection assembly | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | purinergic nucleotide receptor activity | regulation of calcium ion transport | cell motility involved in cerebral cortex radial glia guided migration | regulation of transport | response to organonitrogen compound | potassium ion transmembrane transport | central nervous system development | ion transport | regulation of cell projection organization | G-protein coupled adenosine receptor activity | ameboidal-type cell migration | cellular response to organic substance | positive regulation of cell motility | regulation of microglial cell migration | negative regulation of cell differentiation | regulation of cellular component organization | homotypic cell-cell adhesion | substrate-dependent cell migration, cell extension | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process
GO Cellular Component
basal plasma membrane | intracellular membrane-bounded organelle | basal part of cell | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | plasma membrane | membrane raft | mitochondrion | membrane-bounded organelle | organelle | cell periphery | basolateral plasma membrane | plasma membrane raft | cell surface | intracellular | caveola | membrane
