QuickView for PBX1;jsessionid=5F7715E1237AC1CF6D6630B9A8F1BD6D;jsessionid=299AFCE8679385075A76A9E91EF48CB1;jsessionid=BCF4BDA86AC6A00E598006F8BD1D8FFC;jsessionid=06BFCEE667C974F0FB80A37AAD386955 (gene)

Gene Symbol:

PBX1 Homo sapiens

Full name:

PBX homeobox 1

Synonyms:

CAKUHED, pre-B-cell leukemia transcription factor 1, homeobox protein PBX1, homeobox protein PRL, pre-B-cell leukemia homeobox 1

Genomic Location:

Chr 1: 162795561-163082934

Description:

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-ce...

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This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TCTGGAC_MIR198 ,  GATTGGY_NFY_Q6_01 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  STAT4_01 ,  PU1_Q6 ,  MZF1_01 ,  FOXJ2_02 ,  GGGATGC_MIR3245P ,  OCT1_04 ,  MAZ_Q6 ,  VDR_Q3 ,  OCT1_01 ,  AML_Q6 ,  CATTGTYY_SOX9_B1 ,  AAAYWAACM_HFH4_01 ,  NFY_C ,  ATGGYGGA_UNKNOWN ,  TFIII_Q6 ,  SOX9_B1 ,  CAGGTA_AREB6_01 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  TATA_C ,  PITX2_Q2 ,  HMX1_01 ,  NFY_Q6 ,  CTTTAAR_UNKNOWN ,  TCTCTCC_MIR185 ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  AP2REP_01 ,  CART1_01 ,  STAT5A_04 ,  TEF_Q6 ,  EGR1_01 ,  CACBINDINGPROTEIN_Q6 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  ACAWYAAAG_UNKNOWN ,  YNGTTNNNATT_UNKNOWN ,  PAX4_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-488

Cytogenetic Map:

1q23.3

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