QuickView for PCNA;jsessionid=FBAFF646F576799ECD87CAD815ED8F6F;jsessionid=15CDCF197E942613F1977AECB3D1F08F (gene)
- Gene Symbol:
- Pcna
Rattus norvegicus - Full name:
- proliferating cell nuclear antigen
- Synonyms:
- PCNAR, Pcna/cyclin, proliferating cell nuclear antigen, cyclin
- Genomic Location:
- Chr 3: 120008711-120012673
- Description:
-
cell cycle protein that may contribute to the repair of DNA damage and to cell proliferation caused by exposure to pulmonary toxicants; may influence cell survival in ischaemically compromised tissue
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
E2F_01 , E2F_02 , CCAATNNSNNNGCG_UNKNOWN , CCAWYNNGAAR_UNKNOWN , E2F_Q3 , E2F_Q4 , E2F_Q6 , E2F1_Q3 , E2F1_Q4 , E2F1_Q6
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
DNA N-glycosylase activity | kinase binding | dinucleotide insertion or deletion binding | hormone receptor binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | DNA polymerase binding | estrogen receptor binding | signaling receptor binding | hydrolase activity | mismatched DNA binding | hydrolase activity, hydrolyzing N-glycosyl compounds | MutLalpha complex binding | molecular function regulator | catalytic activity | chromatin binding | DNA insertion or deletion binding | DNA polymerase processivity factor activity | DNA binding | identical protein binding | nuclear hormone receptor binding | damaged DNA binding | hydrolase activity, acting on glycosyl bonds | purine-specific mismatch base pair DNA N-glycosylase activity | organic cyclic compound binding | protein tyrosine kinase binding | protein binding | histone acetyltransferase binding | double-stranded DNA binding | transcription factor binding | enzyme regulator activity | steroid hormone receptor binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | response to radiation | positive regulation of macromolecule biosynthetic process | telomere maintenance | response to nutrient levels | translesion synthesis | response to hormone | negative regulation of cellular process | response to dexamethasone | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | response to drug | regulation of DNA replication | response to antibiotic | regulation of DNA repair | positive regulation of cellular biosynthetic process | cellular process | DNA-dependent DNA replication maintenance of fidelity | cellular homeostasis | response to estradiol | cell cycle DNA replication | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | postreplication repair | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | anatomical structure homeostasis | regeneration | response to hydrogen peroxide | regulation of cellular process | regulation of metabolic process | hepaticobiliary system development | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | positive regulation of response to DNA damage stimulus | response to UV | response to stimulus | cellular response to light stimulus | cellular response to xenobiotic stimulus | response to stress | cellular nitrogen compound biosynthetic process | ovulation cycle | response to L-glutamate | reproduction | rhythmic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | telomere organization | positive regulation of nuclease activity | negative regulation of metabolic process | cellular biosynthetic process | molecular function regulator | positive regulation of deoxyribonuclease activity | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | replication fork processing | cellular response to antibiotic | multicellular organism development | positive regulation of DNA replication | response to amino acid | cellular response to DNA damage stimulus | regulation of catalytic activity | cellular response to oxidative stress | regulation of gene expression | DNA biosynthetic process | response to ketone | cellular response to stress | response to lipid | cell cycle | positive regulation of cellular metabolic process | DNA polymerase processivity factor activity | cellular response to radiation | liver development | regulation of nitrogen compound metabolic process | response to corticosteroid | regulation of transcription by RNA polymerase II | response to nutrient | response to oxidative stress | positive regulation of hydrolase activity | telomere maintenance via semi-conservative replication | biosynthetic process | response to cadmium ion | aromatic compound biosynthetic process | response to toxic substance | mismatch repair | response to xenobiotic stimulus | cellular response to UV | cellular response to drug | DNA strand elongation | regulation of cellular metabolic process | liver regeneration | base-excision repair | heart development | homeostatic process | regulation of RNA metabolic process | positive regulation of molecular function | multicellular organism reproduction | response to organic substance | gland development | DNA metabolic process | response to antineoplastic agent | anatomical structure development | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular response to hydrogen peroxide | leading strand elongation | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | base-excision repair, gap-filling | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | estrous cycle | regulation of transcription, DNA-templated | response to organic cyclic compound | enzyme regulator activity | cellular macromolecule biosynthetic process | mitotic telomere maintenance via semi-conservative replication | nuclear DNA replication | positive regulation of DNA metabolic process | developmental process | organelle organization | negative regulation of transcription by RNA polymerase II | DNA synthesis involved in DNA repair | DNA strand elongation involved in DNA replication | response to organonitrogen compound | epithelial cell differentiation | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | response to steroid hormone | DNA replication | circulatory system development | animal organ regeneration | response to glucocorticoid | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear replication fork | microtubule organizing center | protein kinase complex | cell | nuclear lumen | replication fork | intracellular organelle | nuclear body | centrosome | protein-containing complex | nucleoplasm | nuclear chromosome | transferase complex | microtubule cytoskeleton | PCNA complex | nuclear lamina | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | PCNA-p21 complex | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytoskeleton | intracellular | nuclear periphery
