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QuickView for PDE4D;jsessionid=C23D5F14FFECDD3BB0EF72A1C128750B;jsessionid=A764E28E907D83962E6051830F14451A (gene)


Gene Symbol:
Pde4d Rattus norvegicus Rattus norvegicus
Full name:
phosphodiesterase 4D
Synonyms:
PDE3/IVd, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 3',5'-cyclic AMP phosphodiesterase, DPDE3, Phosphodiesterase 4D, cAMP-specific (dunce, cAMP-specific phosphodiesterase PDE4D, cAMP-specific phosphodiesterase splice variant PDE4D8, phosphodiesterase 4D, cAMP specific, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
Genomic Location:
Chr 2: 40820287-41311012
Description:
may contain eight isoforms that display differential expression and activities; isorofms Pde4D6 and Pde4D7 exhibit high affinity for cyclic AMP and are inhibited by rolipram
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
AACTTT_UNKNOWN YY1_01 EVI1_04 CEBPA_01 CEBPB_02 OCT1_01 OCT1_02 OCT1_05 OCT1_06 CREBP1_Q2
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-18 Predicted Gene Targets for miR-183 Predicted Gene Targets for miR-199 Predicted Gene Targets for miR-208 Predicted Gene Targets for miR-219 Predicted Gene Targets for miR-223 Predicted Gene Targets for miR-24 Predicted Gene Targets for miR-25





GO Molecular Function

beta-2 adrenergic receptor binding | cyclic nucleotide binding | cation binding | cAMP binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | adrenergic receptor binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | ion channel binding | ubiquitin-like protein ligase binding | anion binding | ATPase binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | scaffold protein binding | ion binding | organic cyclic compound binding | protein binding | ubiquitin protein ligase binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | G-protein coupled receptor binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | small molecule binding

GO Biological Process

positive regulation of immune response | positive regulation of smooth muscle cell proliferation | positive regulation of heart contraction | negative regulation of phosphorylation | purine ribonucleotide metabolic process | regulation of muscle system process | positive regulation of locomotion | heart process | positive regulation of blood circulation | cell motility | immune response-regulating signaling pathway | nucleoside phosphate catabolic process | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | endothelial cell development | regulation of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of systemic arterial blood pressure by norepinephrine-epinephrine | endothelial cell differentiation | respiratory tube development | T cell receptor signaling pathway | multicellular organism growth | organophosphate catabolic process | negative regulation of protein phosphorylation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | cellular response to epinephrine stimulus | response to organophosphorus | cellular process | organic substance catabolic process | regulation of cell motility | localization | regulation of calcium-mediated signaling | nucleotide metabolic process | negative regulation of signaling | developmental growth | negative regulation of peptidyl-serine phosphorylation | carbohydrate derivative catabolic process | adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate | negative regulation of relaxation of muscle | ribose phosphate metabolic process | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | granulocyte chemotaxis | negative regulation of cellular metabolic process | tissue development | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | regulation of relaxation of muscle | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | smooth muscle contraction | cellular component organization | regulation of systemic arterial blood pressure mediated by a chemical signal | muscle contraction | response to stimulus | positive regulation of blood pressure | purine nucleotide metabolic process | respiratory system development | neutrophil chemotaxis | positive regulation of immune system process | positive regulation of protein metabolic process | adenylate cyclase-activating adrenergic receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of heart rate by chemical signal | regulation of blood circulation | regulation of cardiac muscle cell contraction | positive regulation of cell-cell adhesion | epithelial cell development | regulation of smooth muscle cell migration | regulation of heart rate | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | immune response-activating signal transduction | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | cellular component assembly | regulation of cell adhesion | cellular biosynthetic process | nucleobase-containing compound catabolic process | cell chemotaxis | leukocyte migration | locomotion | response to nitrogen compound | regulation of calcium ion transport into cytosol | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | endothelium development | negative regulation of phosphate metabolic process | multicellular organism development | cell migration | phosphorus metabolic process | response to purine-containing compound | learning or memory | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | positive regulation of smooth muscle cell migration | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of muscle contraction | cyclic nucleotide metabolic process | regulation of phosphorylation | response to lipid | nervous system process | regulation of blood pressure | response to epinephrine | organophosphate metabolic process | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | establishment of endothelial barrier | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | regulation of cellular component movement | negative regulation of relaxation of cardiac muscle | cAMP catabolic process | nucleobase-containing small molecule metabolic process | second-messenger-mediated signaling | cognition | regulation of release of sequestered calcium ion into cytosol | positive regulation of cell migration | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | regulation of calcium ion transmembrane transport | nucleotide catabolic process | regulation of heart contraction | phosphate-containing compound metabolic process | regulation of striated muscle contraction | response to bacterium | regulation of relaxation of cardiac muscle | cell communication | regulation of cellular metabolic process | response to catecholamine | cyclic-nucleotide-mediated signaling | regulation of cardiac muscle contraction | regulation of protein metabolic process | aromatic compound catabolic process | regulation of cAMP-mediated signaling | leukocyte chemotaxis | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of ryanodine-sensitive calcium-release channel activity | cyclic nucleotide catabolic process | cAMP metabolic process | positive regulation of heart rate | regulation of signaling receptor activity | response to monoamine | protein-containing complex assembly | activation of immune response | positive regulation of protein modification process | response to organic substance | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | cAMP-mediated signaling | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of interleukin-5 production | negative regulation of heart contraction | behavior | G-protein coupled receptor signaling pathway involved in heart process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of sequestering of calcium ion | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of interleukin-5 production | cellular response to cAMP | regulation of phosphate metabolic process | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | positive regulation of cytokine production | response to cAMP | lung development | regulation of peptidyl-serine phosphorylation | memory | negative regulation of protein metabolic process | organonitrogen compound catabolic process | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | cell development | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | regulation of cytokine production | response to biotic stimulus | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | positive regulation of heart rate by epinephrine-norepinephrine | negative regulation of cAMP-mediated signaling | regulation of calcium ion transport | positive regulation of interleukin-2 production | tube development | carbohydrate derivative metabolic process | regulation of transport | adrenergic receptor signaling pathway | regulation of cell-cell adhesion | regulation of cation channel activity | response to organonitrogen compound | epithelial cell differentiation | heterocycle metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | regulation of calcium ion transmembrane transporter activity | purine ribonucleotide catabolic process | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | regulation of smooth muscle cell proliferation | positive regulation of cell motility | neutrophil migration | aging | chemotaxis | muscle system process | response to other organism | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | purine nucleotide catabolic process | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | organelle membrane | microtubule organizing center | nuclear membrane | voltage-gated calcium channel complex | cell | plasma membrane protein complex | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | contractile fiber | apical part of cell | centrosome | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | nuclear envelope | microtubule cytoskeleton | calcium channel complex | membrane-bounded organelle | nucleus | organelle | cell periphery | transmembrane transporter complex | cation channel complex | ion channel complex | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex