QuickView for PDGFRB;jsessionid=9F68EF08CB8C49148706D2E282580348;jsessionid=94B5A5D5FEEB8584666EF7A9A71139CB (gene)
- Gene Symbol:
- Pdgfrb
Rattus norvegicus - Full name:
- platelet derived growth factor receptor beta
- Synonyms:
- PDGFR-1, platelet-derived growth factor receptor beta, CD140 antigen-like family member B, PDGF-R-beta, PDGFR-beta, Platelet-derived growth factor receptor, beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet derived growth factor receptor, beta polypeptide, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta variant 1
- Genomic Location:
- Chr 18: 57014475-57053581
- Description:
-
binds platelet derived growth factor BB homodimer
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
phosphatidylinositol 3-kinase binding | kinase binding | transmembrane receptor protein tyrosine kinase activity | vascular endothelial growth factor binding | protein kinase binding | transmembrane signaling receptor activity | platelet-derived growth factor receptor binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | platelet-derived growth factor binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | platelet-derived growth factor-activated receptor activity | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | kinase activity | heterocyclic compound binding | platelet-derived growth factor beta-receptor activity | small molecule binding
GO Biological Process
positive regulation of smooth muscle cell proliferation | regulation of ERK1 and ERK2 cascade | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of dephosphorylation | actin filament-based process | positive regulation of Ras protein signal transduction | S-shaped body morphogenesis | positive regulation of cellular component organization | cell motility | lung growth | developmental process involved in reproduction | muscle tissue development | intracellular signal transduction | cellular response to platelet-derived growth factor stimulus | positive regulation of apoptotic process | cell migration involved in kidney development | regulation of localization | positive regulation of collagen metabolic process | cell proliferation involved in kidney development | gonad development | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | eye development | cell proliferation involved in metanephros development | phosphatidylinositol metabolic process | actin cytoskeleton organization | response to hormone | positive regulation of phosphoprotein phosphatase activity | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | regulation of phosphatase activity | cell differentiation | positive regulation of fibroblast proliferation | respiratory tube development | striated muscle cell development | glomerulus development | response to drug | organ growth | metanephric glomerulus development | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | cardiac cell development | response to antibiotic | mesenchyme development | tissue homeostasis | phospholipid metabolic process | blood vessel morphogenesis | positive regulation of dephosphorylation | positive regulation of phosphatidylinositol 3-kinase activity | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | negative regulation of signaling | developmental growth | positive regulation of reactive oxygen species metabolic process | reproductive system development | response to estradiol | regulation of mitotic nuclear division | immune system development | positive regulation of protein kinase activity | regulation of chemotaxis | negative regulation of apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | tissue development | metanephric nephron development | muscle structure development | anatomical structure homeostasis | muscle cell differentiation | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | metanephric nephron morphogenesis | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway | positive regulation of cellular protein metabolic process | coronary vasculature morphogenesis | cellular component organization | cellular lipid metabolic process | metanephric glomerular mesangium development | urogenital system development | development of primary sexual characteristics | glycosaminoglycan biosynthetic process | response to stimulus | vasculature development | muscle cell development | cellular response to vascular endothelial growth factor stimulus | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | regulation of cell proliferation | multicellular organismal homeostasis | tube morphogenesis | cardiac muscle tissue development | regulation of smooth muscle cell migration | positive regulation of phosphatase activity | phosphatidylinositol-mediated signaling | supramolecular fiber organization | positive regulation of cell activation | reproduction | cardiovascular system development | glomerular mesangial cell proliferation | positive regulation of lipase activity | platelet-derived growth factor receptor-beta signaling pathway | metanephric glomerulus morphogenesis | metanephros morphogenesis | carbohydrate derivative biosynthetic process | positive regulation of protein serine/threonine kinase activity | hemopoiesis | cellular component assembly | protein modification process | kidney development | embryo development | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | cell chemotaxis | positive regulation of protein dephosphorylation | blood vessel development | locomotion | positive regulation of phospholipase C activity | organelle assembly | smooth muscle cell chemotaxis | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | glomerulus vasculature development | regulation of MAPK cascade | phosphorus metabolic process | platelet-derived growth factor-activated receptor activity | regulation of collagen biosynthetic process | positive regulation of smooth muscle cell migration | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | kidney morphogenesis | wound healing | positive regulation of calcium ion import | artery development | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of small GTPase mediated signal transduction | positive regulation of chemotaxis | platelet-derived growth factor receptor signaling pathway | response to lipid | metanephric glomerular mesangial cell proliferation involved in metanephros development | organophosphate metabolic process | coronary vasculature development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | metanephric mesenchymal cell migration | regulation of hepatic stellate cell activation | positive regulation of Rho protein signal transduction | vascular endothelial growth factor signaling pathway | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | cardiocyte differentiation | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | regulation of cellular component movement | response to oxidative stress | metanephric comma-shaped body morphogenesis | positive regulation of hydrolase activity | response to platelet-derived growth factor | positive regulation of cell migration | cell migration involved in vasculogenesis | regulation of Rho protein signal transduction | cell proliferation | biosynthetic process | cardiac myofibril assembly | regulation of cellular protein metabolic process | cardiac muscle cell development | angiogenesis | response to hyperoxia | phosphorylation | actomyosin structure organization | angiogenesis involved in coronary vascular morphogenesis | regulation of phospholipase activity | inositol lipid-mediated signaling | glomerulus morphogenesis | response to toxic substance | endocrine system development | protein phosphorylation | phosphate-containing compound metabolic process | sensory organ development | regulation of lipid kinase activity | response to estrogen | chordate embryonic development | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | smooth muscle cell migration | skeletal system morphogenesis | metanephros development | positive regulation of DNA biosynthetic process | regulation of collagen metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | vasculogenesis | inner ear development | glomerular capillary formation | heart development | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | glycerolipid metabolic process | renal system development | positive regulation of transport | response to retinoic acid | regulation of phospholipid metabolic process | striated muscle cell differentiation | positive regulation of hepatic stellate cell activation | regulation of mitotic cell cycle | nephron development | smooth muscle tissue development | protein tyrosine kinase activity | regulation of phospholipase C activity | cell migration involved in heart development | positive regulation of molecular function | development of primary male sexual characteristics | protein metabolic process | muscle cell migration | regulation of fibroblast proliferation | positive regulation of protein modification process | response to organic substance | gland development | artery morphogenesis | retina development in camera-type eye | regulation of protein dephosphorylation | regulation of kinase activity | male sex differentiation | response to wounding | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | aorta development | positive regulation of small GTPase mediated signal transduction | metabolic process | negative regulation of programmed cell death | embryonic organ development | male gonad development | ear development | adrenal gland development | positive regulation of cell death | metanephric glomerulus vasculature development | protein kinase activity | organic substance metabolic process | connective tissue development | nephron morphogenesis | animal organ development | positive regulation of ion transport | response to reactive oxygen species | regulation of cell activation | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | myofibril assembly | positive regulation of kinase activity | regulation of phosphate metabolic process | cytoskeleton organization | metanephric glomerular capillary formation | positive regulation of metanephric mesenchymal cell migration | positive regulation of phospholipase activity | positive regulation of MAPK cascade | aorta morphogenesis | lung development | camera-type eye development | comma-shaped body morphogenesis | anatomical structure formation involved in morphogenesis | cardiac muscle cell differentiation | regulation of calcium ion import | response to fluid shear stress | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | cell development | positive regulation of phosphorylation | cellular protein metabolic process | regulation of Ras protein signal transduction | anatomical structure morphogenesis | positive regulation of MAP kinase activity | reproductive structure development | regulation of developmental process | regulation of ion transport | glycerophospholipid metabolic process | regulation of phosphoprotein phosphatase activity | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | regulation of DNA biosynthetic process | cell migration involved in coronary angiogenesis | positive regulation of cell cycle process | regulation of calcium ion transport | cellular protein modification process | tube development | carbohydrate derivative metabolic process | regulation of transport | regulation of reactive oxygen species metabolic process | metanephric mesenchyme development | positive regulation of kidney development | positive regulation of lipid kinase activity | transmembrane receptor protein tyrosine kinase signaling pathway | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of lipid metabolic process | retina vasculature development in camera-type eye | skeletal system development | immune system process | positive regulation of collagen biosynthetic process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | sex differentiation | regulation of smooth muscle cell proliferation | positive regulation of cell motility | negative regulation of cell death | circulatory system development | aging | chemotaxis | platelet-derived growth factor beta-receptor activity | regulation of cellular component organization | positive regulation of calcium ion transport | regulation of cytoskeleton organization | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | macromolecule metabolic process | metanephric S-shaped body morphogenesis | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | cytoplasmic vesicle | cell | vacuolar lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | receptor complex | apical part of cell | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | vacuole | vesicle | lytic vacuole | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | lysosome | cell periphery | membrane-enclosed lumen | lysosomal lumen | intracellular vesicle | cell surface | intracellular | membrane | intrinsic component of plasma membrane
