QuickView for PFKFB1;jsessionid=3B47A6AC7774A3BDAA3102D8D5F3AD5D;jsessionid=A3B2C1CC0D0717B23FA030FD6E8BE05A;jsessionid=A7208EE3DD40B7C6F0747C6533301ED1 (gene)
- Gene Symbol:
- Pfkfb1
Rattus norvegicus - Full name:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
- Synonyms:
- PFRX, Pfkfb01, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1, 6-PF2-K/Fru-2,6-P2ase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6PF-2-K/Fru-2,6-P2ASE liver isozyme, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, PFK2/FBPase2
- Genomic Location:
- Chr X: 39838444-39886105
- Description:
-
bifunctional enzyme; catalyzes synthesis and degradation of fructose 2,6-bisphosphate, a ubiquitous stimulator of glycolysis
- Orthologs:
- Homo sapiens , Mus musculus , C. elegans , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
| Transcripts Names |
|---|
| NM_012621 |
| NM_001271063 |
| NM_001271064 |
| XM_006256791 |
| XM_008773125 |
| XM_008773123 |
| XM_006256790 |
| XM_008773124 |
GO Molecular Function
phosphofructokinase activity | fructose-2,6-bisphosphate 2-phosphatase activity | kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | phosphatase activity | hydrolase activity | sugar-phosphatase activity | 6-phosphofructo-2-kinase activity | fructose-6-phosphate binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphoric ester hydrolase activity | phosphotransferase activity, alcohol group as acceptor | transferase activity | carbohydrate kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | carbohydrate phosphatase activity | small molecule binding
GO Biological Process
phosphofructokinase activity | response to extracellular stimulus | response to nutrient levels | fructose-2,6-bisphosphate 2-phosphatase activity | positive regulation of glucokinase activity | regulation of carbohydrate metabolic process | response to hormone | positive regulation of phosphate metabolic process | positive regulation of hexokinase activity | response to organophosphorus | cellular process | positive regulation of catalytic activity | response to peptide hormone | regeneration | regulation of cellular process | regulation of metabolic process | phosphatase activity | response to stimulus | sugar-phosphatase activity | response to stress | 6-phosphofructo-2-kinase activity | response to peptide | response to starvation | fructose metabolic process | response to nitrogen compound | system development | multicellular organism development | phosphorus metabolic process | response to purine-containing compound | regulation of catalytic activity | regulation of phosphorylation | response to lipid | organophosphate metabolic process | positive regulation of cellular metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | response to corticosteroid | carbohydrate phosphorylation | phosphorylation | carbohydrate metabolic process | phosphate-containing compound metabolic process | regulation of cellular metabolic process | positive regulation of molecular function | response to glucagon | response to organic substance | fructose 2,6-bisphosphate metabolic process | regulation of kinase activity | response to insulin | anatomical structure development | regulation of glucose metabolic process | metabolic process | hexose metabolic process | organic substance metabolic process | animal organ development | positive regulation of kinase activity | regulation of phosphate metabolic process | carbohydrate kinase activity | response to cAMP | positive regulation of carbohydrate metabolic process | dephosphorylation | response to organic cyclic compound | positive regulation of phosphorylation | kinase activity | developmental process | carbohydrate derivative metabolic process | response to organonitrogen compound | positive regulation of metabolic process | cellular metabolic process | response to steroid hormone | carbohydrate phosphatase activity | animal organ regeneration | response to glucocorticoid | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
catalytic complex | cell | cytoplasm | protein-containing complex | transferase complex | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex | cytosol | intracellular
