QuickView for PINK1;jsessionid=43F0DD9FAA73303C2B7D4A41AD96D8C5;jsessionid=247DC592416F6B69595ABE97A9F20C5D;jsessionid=5AD78763B85E7C1F099DEF506A500C6E;jsessionid=4654593EE2D07076269C05D578F3AFB4 (gene)
- Gene Symbol:
- PINK1
Homo sapiens - Full name:
- PTEN induced putative kinase 1
- Synonyms:
- BRPK, PARK6, serine/threonine-protein kinase PINK1, mitochondrial, PTEN-induced putative kinase protein 1, protein kinase BRPK
- Genomic Location:
- Chr 1: 20832535-20850591
- Description:
-
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Danio rerio , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p36.12
GO Molecular Function
kinase binding | enzyme activator activity | calcium-dependent protein kinase activity | cation binding | protein kinase binding | magnesium ion binding | protein kinase B binding | enzyme binding | ribonucleotide binding | peptidase activator activity | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | C3HC4-type RING finger domain binding | purine ribonucleoside triphosphate binding | protein binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | protease binding | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
negative regulation of JNK cascade | negative regulation of phosphorylation | positive regulation of deacetylase activity | regulation of hydrogen peroxide-induced cell death | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | regulation of dephosphorylation | regulation of intracellular protein transport | negative regulation of MAPK cascade | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | positive regulation of ion transmembrane transporter activity | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | proteolysis | regulation of vacuole organization | protein stabilization | protein localization to mitochondrion | regulation of localization | positive regulation of DNA-binding transcription factor activity | macroautophagy | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | peptidyl-amino acid modification | regulation of mitochondrial fission | establishment of localization | regulation of autophagy | negative regulation of neuron death | negative regulation of cellular process | positive regulation of histone deacetylase activity | positive regulation of developmental process | positive regulation of signaling receptor activity | negative regulation of mitochondrion organization | response to drug | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | positive regulation of cation channel activity | regulation of organelle organization | calcium-dependent protein kinase activity | autophagy of mitochondrion | regulation of neuron death | positive regulation of dephosphorylation | positive regulation of oxidative phosphorylation | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | regulation of catecholamine secretion | organic substance catabolic process | negative regulation of oxidative stress-induced neuron death | localization | proteolysis involved in cellular protein catabolic process | positive regulation of synaptic transmission | regulation of ubiquitin-protein transferase activity | regulation of mitochondrial membrane potential | negative regulation of macroautophagy | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | response to hydrogen sulfide | TOR signaling | cellular respiration | establishment of protein localization to mitochondrion | positive regulation of protein kinase activity | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | response to hypoxia | positive regulation of release of cytochrome c from mitochondria | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of autophagosome assembly | regulation of oxidative phosphorylation | negative regulation of apoptotic signaling pathway | negative regulation of hydrogen peroxide-mediated programmed cell death | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | peptidase activator activity | positive regulation of translation | positive regulation of cellular protein metabolic process | negative regulation of oxidative stress-induced cell death | negative regulation of response to drug | maintenance of protein location in mitochondrion | cellular component organization | positive regulation of autophagy of mitochondrion | positive regulation of synaptic transmission, dopaminergic | response to stimulus | lysosomal transport | regulation of mitochondrial ATP synthesis coupled electron transport | regulation of cellular protein localization | positive regulation of protein targeting to mitochondrion | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of cellular protein catabolic process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | cellular response to hypoxia | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | positive regulation of cation transmembrane transport | positive regulation of cellular protein localization | vacuolar transport | regulation of response to drug | posttranscriptional regulation of gene expression | regulation of protein ubiquitination | electron transport chain | positive regulation of protein deacetylation | protein serine/threonine kinase activity | regulation of neurotransmitter receptor activity | cellular protein catabolic process | cellular localization | regulation of histone deacetylase activity | positive regulation of proteolysis | cellular response to toxic substance | maintenance of protein localization in organelle | positive regulation of mitophagy in response to mitochondrial depolarization | response to ischemia | regulation of macroautophagy | regulation of protein transport | negative regulation of metabolic process | protein modification process | negative regulation of autophagosome assembly | mitochondrion to lysosome transport | regulation of peptide transport | modulation of chemical synaptic transmission | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | mitochondrion organization | macromolecule modification | positive regulation of protein dephosphorylation | negative regulation of autophagy of mitochondrion | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | positive regulation of mitochondrion organization | regulation of nucleic acid-templated transcription | regulation of membrane potential | regulation of cellular response to stress | negative regulation of neuron apoptotic process | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of cellular response to hypoxia | regulation of protein stability | negative regulation of phosphate metabolic process | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | positive regulation of catecholamine secretion | positive regulation of mitochondrial electron transport, NADH to ubiquinone | positive regulation of protein kinase B signaling | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | positive regulation of chromosome organization | regulation of gene expression | positive regulation of secretion | cellular response to stress | protein catabolic process | positive regulation of intracellular protein transport | negative regulation of hydrogen peroxide-induced cell death | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | mitochondrial transport | positive regulation of ion transmembrane transport | cellular response to oxygen levels | positive regulation of ATP biosynthetic process | protein autophosphorylation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | vesicle-mediated transport | response to oxidative stress | regulation of synaptic transmission, dopaminergic | protein localization to organelle | positive regulation of hydrolase activity | activation of protein kinase B activity | positive regulation of cellular respiration | regulation of cellular protein metabolic process | phosphorylation | positive regulation of NMDA glutamate receptor activity | negative regulation of stress-activated MAPK cascade | regulation of synaptic vesicle transport | response to toxic substance | regulation of hydrogen peroxide metabolic process | regulation of apoptotic signaling pathway | protein phosphorylation | negative regulation of hydrogen peroxide-induced neuron death | phosphate-containing compound metabolic process | autophagy | negative regulation of autophagy | cellular response to drug | regulation of mitochondrion organization | regulation of cellular response to drug | maintenance of protein location | positive regulation of histone deacetylation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein deacetylation | positive regulation of response to drug | regulation of neuron apoptotic process | positive regulation of transporter activity | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | regulation of dopamine secretion | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | organelle disassembly | regulation of autophagy of mitochondrion | positive regulation of molecular function | regulation of signaling receptor activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | protein ubiquitination | regulation of cellular respiration | regulation of protein dephosphorylation | positive regulation of free ubiquitin chain polymerization | regulation of kinase activity | regulation of response to reactive oxygen species | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | establishment of protein localization to organelle | peptidyl-serine autophosphorylation | metabolic process | negative regulation of response to oxidative stress | regulation of protein catabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | oxidation-reduction process | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway | cellular protein localization | regulation of vesicle-mediated transport | regulation of secretion | positive regulation of cell death | protein kinase activity | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of gene expression | positive regulation of ion transport | positive regulation of histone modification | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | maintenance of protein location in cell | regulation of ATP metabolic process | regulation of phosphate metabolic process | regulation of chromosome organization | TORC2 signaling | regulation of ion transmembrane transport | positive regulation of autophagy | establishment of protein localization | positive regulation of macroautophagy | positive regulation of intracellular transport | regulation of JNK cascade | regulation of mitochondrial electron transport, NADH to ubiquinone | positive regulation of protein transport | regulation of peptidyl-serine phosphorylation | ubiquitin-dependent protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | response to mitochondrial depolarisation | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of transmembrane transporter activity | positive regulation of mitochondrial fission | protein localization | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of dopamine secretion | enzyme regulator activity | cellular macromolecule localization | regulation of NMDA receptor activity | regulation of developmental process | regulation of ion transport | energy derivation by oxidation of organic compounds | kinase activity | organelle organization | positive regulation of mitophagy | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of cristae formation | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of mitochondrial fission | positive regulation of protein polymerization | regulation of cation channel activity | regulation of histone deacetylation | regulation of glutamate receptor signaling pathway | positive regulation of ubiquitin-protein transferase activity | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | positive regulation of glutamate receptor signaling pathway | cellular metabolic process | regulation of protein localization | regulation of cell death | modification-dependent protein catabolic process | regulation of organelle assembly | regulation of translation | negative regulation of cell death | cellular response to hydrogen sulfide | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | negative regulation of cellular response to hypoxia | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | positive regulation of mitochondrial ATP synthesis coupled electron transport | maintenance of location in cell | respiratory electron transport chain | regulation of protein targeting to mitochondrion | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
integral component of organelle membrane | integral component of membrane | mitochondrial intermembrane space | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | neuron projection | organelle membrane | Lewy body | cell body | cell | organelle outer membrane | distal axon | intrinsic component of membrane | cytoplasm | outer mitochondrial membrane protein complex | intracellular organelle | ubiquitin ligase complex | inclusion body | glial cell projection | protein-containing complex | cell projection | chromatin | transferase complex | perinuclear region of cytoplasm | TORC2 complex | mitochondrion | site of polarized growth | mitochondrial outer membrane translocase complex | intrinsic component of mitochondrial outer membrane | membrane-bounded organelle | astrocyte projection | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | axon | membrane-enclosed lumen | outer membrane | growth cone | integral component of mitochondrial membrane | mitochondrial membrane | cytosol | cytoskeleton | intracellular | integral component of mitochondrial outer membrane | membrane
