QuickView for PLA2G4A;jsessionid=3DB9A856912E5B79DF9430246A1B6547;jsessionid=9028C3D644F152044DAF6EB56ACC1362 (gene)
- Gene Symbol:
- Pla2g4a
Rattus norvegicus - Full name:
- phospholipase A2 group IVA
- Synonyms:
- Pla2c, Pla2g4, cPLA2, cytosolic phospholipase A2, phospholipase A2 cytosolic, phospholipase A2, group IVA (cytosolic, calcium-dependent)
- Genomic Location:
- Chr 13: 64135723-64280803
- Description:
-
catalyzes the synthesis of COX-2 substrate arachidonic acid (AA); may play a role in epileptogenesis
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
calcium-dependent phospholipase A2 activity | cation binding | phospholipase activity | enzyme binding | lipid binding | carboxylic ester hydrolase activity | hydrolase activity | phospholipid binding | catalytic activity | anion binding | phospholipase A2 activity | hydrolase activity, acting on ester bonds | ion binding | lipase activity | phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) | protein binding | histone acetyltransferase binding | lysophospholipase activity | calcium ion binding | calcium-dependent phospholipid binding | metal ion binding | phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO Biological Process
response to extracellular stimulus | long-chain fatty acid transport | response to nutrient levels | positive regulation of cellular component organization | response to lipopolysaccharide | developmental process involved in reproduction | positive regulation of apoptotic process | regulation of localization | gonad development | lipid transport | regulation of programmed cell death | female gonad development | establishment of localization | response to hormone | positive regulation of developmental process | response to metal ion | maternal placenta development | response to drug | organophosphate catabolic process | positive regulation of biomineral tissue development | regulation of organelle organization | response to antibiotic | tissue homeostasis | phospholipid metabolic process | positive regulation of cellular biosynthetic process | cellular process | secretion | organic substance catabolic process | monocarboxylic acid transport | localization | reproductive system development | female pregnancy | anion transport | multicellular organismal reproductive process | macromolecule localization | response to inorganic substance | regulation of bone mineralization | tissue development | gamete generation | anatomical structure homeostasis | positive regulation of unsaturated fatty acid biosynthetic process | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | positive regulation of vesicle fusion | regulation of metabolic process | catabolic process | icosanoid biosynthetic process | cellular lipid metabolic process | luteolysis | development of primary sexual characteristics | response to stimulus | ovulation | female gamete generation | acid secretion | monocarboxylic acid metabolic process | regulation of fatty acid biosynthetic process | response to stress | glycerophospholipid catabolic process | regulation of cell proliferation | positive regulation of lipid biosynthetic process | ovulation cycle | multicellular organismal homeostasis | development of primary female sexual characteristics | reproduction | response to temperature stimulus | rhythmic process | response to molecule of bacterial origin | response to vitamin D | cellular biosynthetic process | ovulation from ovarian follicle | regulation of fever generation | response to nitrogen compound | chemical homeostasis within a tissue | response to external biotic stimulus | system development | reproductive process | positive regulation of organelle organization | cellular response to antibiotic | multicellular organism development | phosphorus metabolic process | positive regulation of inflammatory response | response to methylmercury | lipid metabolic process | regulation of ossification | regulation of acute inflammatory response | arachidonic acid secretion | fatty acid transport | organic substance transport | response to lipid | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of heat generation | small molecule metabolic process | response to corticosteroid | phospholipid catabolic process | response to nutrient | response to lithium ion | response to oxidative stress | organic acid transport | regulation of fatty acid metabolic process | biosynthetic process | positive regulation of ossification | surfactant homeostasis | organic anion transport | positive regulation of fatty acid biosynthetic process | response to toxic substance | phosphate-containing compound metabolic process | ovulation cycle process | response to bacterium | regulation of cellular metabolic process | cellular lipid catabolic process | homeostatic process | positive regulation of cell proliferation | glycerolipid metabolic process | positive regulation of transport | regulation of vesicle fusion | regulation of lipid biosynthetic process | regulation of prostaglandin biosynthetic process | long-chain fatty acid metabolic process | decidualization | carboxylic acid metabolic process | multicellular organism reproduction | maternal process involved in female pregnancy | response to organic substance | positive regulation of fatty acid metabolic process | anatomical structure development | metabolic process | lipid localization | regulation of vesicle-mediated transport | chemical homeostasis | positive regulation of cell death | lipid catabolic process | organic substance metabolic process | positive regulation of acute inflammatory response | response to vitamin | animal organ development | response to reactive oxygen species | positive regulation of programmed cell death | response to heat | fatty acid metabolic process | icosanoid metabolic process | positive regulation of fever generation | response to organic cyclic compound | positive regulation of prostaglandin biosynthetic process | organic acid metabolic process | carboxylic acid transport | response to biotic stimulus | reproductive structure development | regulation of cellular ketone metabolic process | regulation of developmental process | glycerophospholipid metabolic process | developmental process | regulation of transport | response to organonitrogen compound | response to calcium ion | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | ion transport | cellular metabolic process | placenta development | female sex differentiation | regulation of cell death | sex differentiation | response to steroid hormone | regulation of inflammatory response | aging | arachidonic acid metabolic process | sexual reproduction | regulation of cellular component organization | positive regulation of bone mineralization | response to other organism | response to glucocorticoid | multicellular organismal process
GO Cellular Component
secretory granule | zymogen granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | secretory vesicle | endomembrane system | vesicle | lipid droplet | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular vesicle | intracellular
