QuickView for PLAT;jsessionid=E20746CCE46830A7EF5877E8C390BEBA;jsessionid=CCC6C9C0DA78CB881975A42AEE9A5610 (gene)

Gene Symbol:

Plat Mus musculus

Full name:

plasminogen activator, tissue

Synonyms:

AU020998, AW212668, D8Ertd2e, tPA, tissue-type plasminogen activator, t-plasminogen activator

Genomic Location:

Chr 8: 23868240-23893316

Description:

This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological p...

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This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PXR_Q2 ,  TGGNNNNNNKCCAR_UNKNOWN ,  TTANTCA_UNKNOWN ,  TTCYRGAA_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  GGGTGGRR_PAX4_03 ,  RGAGGAARY_PU1_Q6 ,  GGGCGGR_SP1_Q6

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