QuickView for PML;jsessionid=F6861AF86A48B6A30147C44EEA6F1C71;jsessionid=85772C4191A53DAEEEA68094281E4739;jsessionid=8B1A4F49D82B51B85A80FCB98D62BDA1 (gene)
- Gene Symbol:
- Pml
Mus musculus - Full name:
- promyelocytic leukemia
- Synonyms:
- 1200009E24Rik, AI661194, Trim19, protein PML, probable transcription factor PML
- Genomic Location:
- Chr 9: 58066349-58097593
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
P300_01 , ISRE_01 , P53_02 , ETS1_B , P53_DECAMER_Q2 , ETS_Q4 , CTCAAGA_MIR526B , CAGCTG_AP4_Q5 , MGGAAGTG_GABP_B , RGAGGAARY_PU1_Q6
| Transcripts Names |
|---|
| NM_008884 |
| NM_178087 |
| XM_006510864 |
| XM_017313212 |
| XM_006510861 |
| NM_001311088 |
| XM_006510860 |
| XM_006510862 |
GO Molecular Function
cobalt ion binding | cation binding | enzyme binding | nucleic acid binding | catalytic activity | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | DNA binding | identical protein binding | protein heterodimerization activity | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | protein homodimerization activity | zinc ion binding | ubiquitin protein ligase binding | protein dimerization activity | transferase activity | transition metal ion binding | SUMO binding | SUMO transferase activity | transcription coregulator activity | SMAD binding | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | maintenance of protein location in nucleus | regulation of telomere maintenance via telomerase | regulation of interleukin-1 beta production | response to radiation | nucleus organization | regulation of cell cycle process | fibroblast migration | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to virus | response to endoplasmic reticulum stress | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | protein stabilization | regulation of localization | regulation of cell cycle G1/S phase transition | mammary gland duct morphogenesis | morphogenesis of an epithelium | regulation of programmed cell death | peptidyl-amino acid modification | defense response to other organism | negative regulation of viral release from host cell | establishment of localization | regulation of immune system process | myeloid cell differentiation | negative regulation of translation in response to stress | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of fibroblast proliferation | defense response | intrinsic apoptotic signaling pathway in response to DNA damage | protein sumoylation | cellular chemical homeostasis | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | negative regulation of protein secretion | regulation of organelle organization | intracellular transport | negative regulation of DNA metabolic process | regulation of DNA repair | negative regulation of proteolysis | retinoic acid receptor signaling pathway | positive regulation of cellular biosynthetic process | cellular process | negative regulation of DNA biosynthetic process | organic substance catabolic process | circadian regulation of gene expression | localization | cellular homeostasis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | negative regulation of ubiquitin-dependent protein catabolic process | proteolysis involved in cellular protein catabolic process | mitotic DNA integrity checkpoint | protein transport | regulation of MHC class I biosynthetic process | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of viral life cycle | immune system development | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of histone modification | positive regulation of defense response to virus by host | negative regulation of secretion | response to hypoxia | regulation of defense response to virus | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | negative regulation of interleukin-1 production | regulation of apoptotic process | regulation of metabolic process | negative regulation of cytokine secretion | catabolic process | protein import into nucleus | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of viral release from host cell | cellular component organization | negative regulation of translation in response to oxidative stress | calcium ion homeostasis | response to transforming growth factor beta | negative regulation of cellular protein catabolic process | mammary gland morphogenesis | response to UV | regulation of peptide secretion | regulation of vasculature development | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of cellular protein catabolic process | gland morphogenesis | response to stress | intracellular protein transport | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of double-strand break repair | negative regulation of angiogenesis | tube morphogenesis | protein localization to nucleus | positive regulation of cysteine-type endopeptidase activity | regulation of cell cycle phase transition | circadian rhythm | positive regulation of protein deacetylation | programmed cell death | cellular protein catabolic process | cellular localization | positive regulation of mammary gland involution | rhythmic process | positive regulation of proteolysis | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | maintenance of protein localization in organelle | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | metal ion homeostasis | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | apoptotic process | regulation of calcium ion transport into cytosol | response to light stimulus | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | negative regulation of secretion by cell | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | regulation of protein stability | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | phosphorus metabolic process | mammary gland development | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of chromosome organization | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | organic substance transport | cellular response to stress | cell cycle | protein catabolic process | negative regulation of cytokine production | regulation of cell cycle arrest | positive regulation of cellular metabolic process | defense response to virus | regulation of telomerase activity | cellular ion homeostasis | animal organ morphogenesis | PML body organization | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | peptide transport | regulation of transcription by RNA polymerase II | response to oxidative stress | protein localization to organelle | positive regulation of hydrolase activity | import into nucleus | negative regulation of viral process | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | positive regulation of endopeptidase activity | negative regulation of interleukin-1 secretion | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | protein phosphorylation | response to gamma radiation | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | protein import | maintenance of protein location | regulation of telomere maintenance via telomere lengthening | mitotic G1 DNA damage checkpoint | regulation of interleukin-1 production | positive regulation of histone deacetylation | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of protein deacetylation | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | transcription coactivator activity | regulation of RNA metabolic process | viral process | negative regulation of telomere maintenance | common-partner SMAD protein phosphorylation | negative regulation of cell growth | regulation of viral process | apoptotic signaling pathway | cell aging | positive regulation of apoptotic process involved in development | proteasome-mediated ubiquitin-dependent protein catabolic process | intrinsic apoptotic signaling pathway in response to oxidative stress | regulation of mitotic cell cycle | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | regulation of cytokine secretion | positive regulation of cell cycle arrest | cellular response to interleukin-4 | protein-containing complex assembly | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | G1 DNA damage checkpoint | tissue morphogenesis | cell cycle arrest | branching morphogenesis of an epithelial tube | regulation of animal organ morphogenesis | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | entrainment of circadian clock | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | cell fate commitment | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of protein catabolic process | regulation of interleukin-1 beta secretion | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of mitotic cell cycle | cellular protein localization | regulation of tissue remodeling | amide transport | peptidyl-lysine modification | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | regulation of secretion | positive regulation of cell death | regulation of response to DNA damage stimulus | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | regulation of protein secretion | negative regulation of telomere maintenance via telomerase | positive regulation of programmed cell death | nuclear body organization | signal transduction involved in mitotic cell cycle checkpoint | ion homeostasis | protein modification by small protein conjugation or removal | maintenance of protein location in cell | regulation of phosphate metabolic process | regulation of chromosome organization | mammary gland epithelium development | negative regulation of translation | intrinsic apoptotic signaling pathway by p53 class mediator | establishment of protein localization | transcription, DNA-templated | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | ubiquitin-dependent protein catabolic process | transforming growth factor beta receptor signaling pathway | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | positive regulation of protein localization to chromosome, telomeric region | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of chromosome organization | negative regulation of molecular function | cellular senescence | cellular response to leukemia inhibitory factor | signaling | regulation of transcription, DNA-templated | negative regulation of telomere maintenance via telomere lengthening | protein localization | cellular protein metabolic process | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of translation in response to stress | SUMO transferase activity | signal transduction involved in DNA damage checkpoint | response to biotic stimulus | nucleocytoplasmic transport | positive regulation of tissue remodeling | regulation of circadian rhythm | regulation of developmental process | regulation of ion transport | cell death in response to oxidative stress | endoplasmic reticulum calcium ion homeostasis | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | negative regulation of interleukin-1 beta secretion | developmental process | organelle organization | regulation of DNA biosynthetic process | positive regulation of cell cycle process | regulation of cell growth | regulation of calcium ion transport | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of interleukin-1 beta production | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | innate immune response | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | entrainment of circadian clock by photoperiod | transcription coregulator activity | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | photoperiodism | heterocycle metabolic process | regulation of apoptotic process involved in development | regulation of histone deacetylation | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | positive regulation of apoptotic process involved in mammary gland involution | protein targeting | immune system process | mitotic cell cycle checkpoint | cellular metabolic process | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | positive regulation of apoptotic process involved in morphogenesis | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of MHC class I biosynthetic process | modification-dependent protein catabolic process | DNA damage checkpoint | regulation of translation | cell cycle checkpoint | signal transduction by p53 class mediator | regulation of viral life cycle | aging | regulation of ubiquitin-dependent protein catabolic process | branching involved in mammary gland duct morphogenesis | negative regulation of proteolysis involved in cellular protein catabolic process | divalent inorganic cation homeostasis | negative regulation of locomotion | negative regulation of telomerase activity | regulation of cellular component organization | response to ionizing radiation | positive regulation of apoptotic signaling pathway | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | response to interleukin-4 | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | extrinsic component of organelle membrane | extrinsic component of membrane | organelle membrane | nuclear membrane | cytoplasmic vesicle | cell | nuclear lumen | extrinsic component of endoplasmic reticulum membrane | nucleolus | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear body | nuclear outer membrane-endoplasmic reticulum membrane network | PML body | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | nuclear envelope | chromatin | nuclear chromosome | vesicle | chromosome, telomeric region | endosome | membrane-bounded organelle | heterochromatin | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | cytosol | intracellular vesicle | nuclear chromosome, telomeric region | intracellular | membrane | nuclear periphery
